Design, Synthesis and Evaluation of Fluorescent Properties of Benzothiazole Derivatives
文献类型：期刊论文
| 作者 | Sun, Yi-Tao1; Zhang, Chun1; Gao, Li-Xin1,2; Liu, Min-Min1; Yang, Yuting1; Shao, Andong1; Zhou, Yu-Bo2 ; Zhu, Yun-Long3; Li, Jia2; Wang, Wen-Long1
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| 刊名 | CHEMPHYSCHEM
 |
| 出版日期 | 2023-07-18 |
| 页码 | 13 |
| ISSN号 | 1439-4235 |
| DOI | 10.1002/cphc.202300159 |
| 通讯作者 | Zhu, Yun-Long(sequoia113847@163.com) ; Li, Jia(jli@simm.ac.cn) ; Wang, Wen-Long(wenlongwang@jiangnan.edu.cn) |
| 英文摘要 | Fluorescence imaging is conducive to establish a bridge between molecular biology and clinical medicine, and provides new tools for disease process research, early diagnosis, and efficacy evaluation, because of the advantages of rapid imaging and nondestructive detection. Herein, a series of fluorescent molecules with thiadiazole, or thiazole, or benzothiazole cores were designed and synthesized to develop more excellent fluorescent molecules in bio-imaging. According to theoretical and experimental methods, we found that benzothiazole derivative 14 B with conjugate expansion by (4-aminophenyl) ethynyl group was the most excellent fluorescent molecule among all the investigated compounds and exhibited low cytotoxicity and strong blue and green fluorescence by confocal cell imaging. |
| WOS关键词 | DENSITY-FUNCTIONAL THEORY ; MOLECULES ; VISCOSITY ; DISEASE ; PROBE |
| 资助项目 | National Natural Science Foundation of China[22277043] ; National Natural Science Foundation of China[21772068] ; Fundamental Research Funds for the Central Universities[JUSRP121065] ; High Level Personnel Project of Jiangsu Province[JSSCBS20210848] |
| WOS研究方向 | Chemistry ; Physics |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:001030522900001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306788]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhu, Yun-Long; Li, Jia; Wang, Wen-Long |
| 作者单位 | 1.Jiangnan Univ, Sch Life Sci & Hlth Engn, Wuxi 214122, Jiangsu, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Jiangnan Univ, Wuxi Maternal & Child Hlth Hosp, Wuxi Sch Med, Wuxi 214002, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Yi-Tao,Zhang, Chun,Gao, Li-Xin,et al. Design, Synthesis and Evaluation of Fluorescent Properties of Benzothiazole Derivatives[J]. CHEMPHYSCHEM,2023:13. |
| APA | Sun, Yi-Tao.,Zhang, Chun.,Gao, Li-Xin.,Liu, Min-Min.,Yang, Yuting.,...&Wang, Wen-Long.(2023).Design, Synthesis and Evaluation of Fluorescent Properties of Benzothiazole Derivatives.CHEMPHYSCHEM,13. |
| MLA | Sun, Yi-Tao,et al."Design, Synthesis and Evaluation of Fluorescent Properties of Benzothiazole Derivatives".CHEMPHYSCHEM (2023):13. |
入库方式： OAI收割
来源：上海药物研究所
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