中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 新药研究国家重点实验室
ARID3a from the ARID family: structure, role in autoimmune diseases and drug discovery

文献类型：期刊论文

作者Guo, Cheng-cen1; Xu, H. Eric2,3,4; Ma, Xiong1
刊名ACTA PHARMACOLOGICA SINICA
出版日期2023-07-24
页码12
ISSN号1671-4083
关键词transcription factors ARID ARID3a autoimmune diseases systemic lupus erythematosus primary biliary cholangitis
DOI10.1038/s41401-023-01134-2
通讯作者Guo, Cheng-cen(guochengcen@163.com) ; Xu, H. Eric(eric.xu@simm.ac.cn) ; Ma, Xiong(maxiongmd@hotmail.com)
英文摘要The AT-rich interaction domain (ARID) family of DNA-binding proteins is a group of transcription factors and chromatin regulators with a highly conserved ARID domain that recognizes specific AT-rich DNA sequences. Dysfunction of ARID family members has been implicated in various human diseases including cancers and intellectual disability. Among them, ARID3a has gained increasing attention due to its potential involvement in autoimmunity. In this article we provide an overview of the ARID family, focusing on the structure and biological functions of ARID3a. It explores the role of ARID3a in autoreactive B cells and its contribution to autoimmune diseases such as systemic lupus erythematosus and primary biliary cholangitis. Furthermore, we also discuss the potential for drug discovery targeting ARID3a and present a plan for future research in this field.
WOS关键词BRUTONS TYROSINE KINASE ; RICH INTERACTION DOMAIN ; DNA-BINDING DOMAIN ; SYSTEMIC-LUPUS-ERYTHEMATOSUS ; TRANSCRIPTION FACTOR ARID3A ; B-CELL LYMPHOMA ; DEAD RINGER ; EPIGENETIC MODIFICATIONS ; MEDIATED RECRUITMENT ; IMMUNOGLOBULIN GENE
资助项目Ministry of Science and Technology (China)[2018YFA0507002] ; Shanghai Municipal Science and Technology Major Project[2019SHZDZX02] ; CAS Strategic Priority Research Program[XDB37030103] ; National Natural Science Foundation of China[32130022] ; National Natural Science Foundation of China[82121005] ; National Natural Science Foundation of China[81830016] ; National Natural Science Foundation of China[81771732] ; National Natural Science Foundation of China[81620108002] ; Shanghai Municipal Science and Technology Major Project
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
出版者NATURE PUBL GROUP
WOS记录号WOS:001034439600001
源URL[http://119.78.100.183/handle/2S10ELR8/306797]  
专题新药研究国家重点实验室
通讯作者Guo, Cheng-cen; Xu, H. Eric; Ma, Xiong
作者单位1.Shanghai Jiao Tong Univ, Renji Hosp, Shanghai Inst Digest Dis, Sch Med,Dept Gastroenterol & Hepatol, Shanghai 200001, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
推荐引用方式
GB/T 7714		 Guo, Cheng-cen,Xu, H. Eric,Ma, Xiong. ARID3a from the ARID family: structure, role in autoimmune diseases and drug discovery[J]. ACTA PHARMACOLOGICA SINICA,2023:12.
APA Guo, Cheng-cen,Xu, H. Eric,&Ma, Xiong.(2023).ARID3a from the ARID family: structure, role in autoimmune diseases and drug discovery.ACTA PHARMACOLOGICA SINICA,12.
MLA Guo, Cheng-cen,et al."ARID3a from the ARID family: structure, role in autoimmune diseases and drug discovery".ACTA PHARMACOLOGICA SINICA (2023):12.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。