Lactoferrin-Modified Gambogic Acid Liposomes for Colorectal Cancer Treatment
文献类型：期刊论文
| 作者 | Wang, Rong1,2,5; Qu, Jingkun3; Tang, Xueping6; Zhang, Jiaxin2; Ou, Ante2; Li, Qianqian2,5; Chen, Guihua2,6; Zheng, Caihong1; Muhitdinov, Bahtiyor2,7; Huang, Yongzhuo2,3,4
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| 刊名 | MOLECULAR PHARMACEUTICS
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| 出版日期 | 2023-07-28 |
| 卷号 | 20期号:8页码:3925-3936 |
| ISSN号 | 1543-8384 |
| 关键词 | Colorectal cancer Gambogic acid Lactoferrin Liposome Tumor drug delivery |
| DOI | 10.1021/acs.molpharmaceut.3c00052 |
| 通讯作者 | Huang, Yongzhuo(yzhuang@simm.ac.cn) |
| 英文摘要 | Colorectal cancer (CRC) therapy is a big challenge, andseekingan effective and safe drug is a pressing clinical need. Gambogic acidis a potent antineoplastic agent without the drawback of bone marrowsuppression. To improve its druggability (e.g., poor water solubilityand tumor delivery), a lactoferrin-modified gambogic acid liposomaldelivery system (LF-lipo) was developed to enhance the treatment efficacyof CRC. The LF-lipo can specifically bind LRP-1 expressed on colorectalcancer cells to enhance drug delivery to the tumor cells and yieldenhanced therapeutic efficacy. The LF-lipo promoted tumor cell apoptosisand autophagy, reduced reactive oxygen species (ROS) levels in tumorcells, and inhibited angiogenesis; moreover, it could also repolarizetumor-associated macrophages from the M2 to M1 phenotype and induceICD to activate T cells, exhibiting the capability of remodeling thetumor immune microenvironment. The liposomal formulation yielded anefficient and safe treatment outcome and has potential for clinicaltranslation. |
| WOS关键词 | TUMOR-ASSOCIATED MACROPHAGES ; RECEPTOR-RELATED PROTEIN-1 ; PEGYLATED LIPOSOMES ; TISSUE DISTRIBUTION ; PANCREATIC-CANCER ; PHARMACOKINETICS ; EXPRESSION ; EXCRETION ; APOPTOSIS |
| 资助项目 | National Key Research and Development Program of China , China[2021YFC2400600] ; National Key Research and Development Program of China , China[2021YFE0103100] ; NFSC , China[81925035] ; NFSC , China[82050410361] ; CAS President's International Fellowship Initiative[2024VBB0004] ; High-level new Ramp;D institute[2021B0909050003] ; Department of Science and Technology of Guangdong Province[LJ2021001] ; Department of Science and Technology of Guangdong Province ; Zhongshan Municipal Bureau of Science and Technology[CXTD2022011] ; Zhongshan Municipal Bureau of Science and Technology[CPAYLJ201901] ; Chinese Pharmaceutical Association-Yiling Pharm Joint Grants , China ; [2019B090904008] |
| WOS研究方向 | Research & Experimental Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:001039687100001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306812]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Huang, Yongzhuo |
| 作者单位 | 1.Zhejiang Univ, Womens Hosp, Dept Pharm, Sch Med, Hangzhou 310006, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, 138 Xianlin Ave, Nanjing 210023, Peoples R China 4.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528437, Peoples R China 5.Nanchang Univ, Coll Pharm, Nanchang 330006, Peoples R China 6.Guangzhou Univ Chinese Med, Artemisinin Res Ctr, 12 Jichang Rd, Guangzhou 510450, Peoples R China 7.Uzbek Acad Sci, Inst Bioorgan Chem, 83 M Ulughbek St, Tashkent 100125, Uzbekistan |
| 推荐引用方式 GB/T 7714 | Wang, Rong,Qu, Jingkun,Tang, Xueping,et al. Lactoferrin-Modified Gambogic Acid Liposomes for Colorectal Cancer Treatment[J]. MOLECULAR PHARMACEUTICS,2023,20(8):3925-3936. |
| APA | Wang, Rong.,Qu, Jingkun.,Tang, Xueping.,Zhang, Jiaxin.,Ou, Ante.,...&Huang, Yongzhuo.(2023).Lactoferrin-Modified Gambogic Acid Liposomes for Colorectal Cancer Treatment.MOLECULAR PHARMACEUTICS,20(8),3925-3936. |
| MLA | Wang, Rong,et al."Lactoferrin-Modified Gambogic Acid Liposomes for Colorectal Cancer Treatment".MOLECULAR PHARMACEUTICS 20.8(2023):3925-3936. |
入库方式： OAI收割
来源：上海药物研究所
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