Understanding neural mechanisms of mechanical itch
文献类型：期刊论文
| 作者 | Feng, Jing2,3,4; Duan, Bo1,5 |
| 刊名 | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
 |
| 出版日期 | 2023-07-01 |
| 卷号 | 152期号:1页码:32-35 |
| ISSN号 | 0091-6749 |
| 关键词 | Mechanical itch alloknesis neural circuit Piezo1 Piezo2 |
| DOI | 10.1016/j.jaci.2023.05.002 |
| 通讯作者 | Feng, Jing(fengjing@simm.ac.cn) ; Duan, Bo(bduan@umich.edu) |
| 英文摘要 | Chronic itch, which is associated with many skin disorders and systemic diseases, is often difficult to treat and can greatly affect quality of life. Patients with chronic itch commonly have both peripheral and central sensitization of itch signaling pathways, which enables pruritogens to elicit an exaggerated itch response (known as chemical itch) and allows innocuous mechanical stimuli to evoke itch sensation (known as mechanical itch), resulting in persistent and ongoing itch. Fully understanding the mechanism of itch sensitization is critical for designing success-ful therapeutic strategies to treat chronic itch. In recent years, significant progress has been made in identifying the molecular, cellular, and circuit mechanisms underlying chemical itch.1 How-ever, understanding the pathways and mechanisms of mechanical itch associated with both acute and chronic itch is still in its early stages. |
| 资助项目 | National Institute of Neurological Disorders and Stroke of the National Institutes of Health[5R01NS109170] ; National Institute of Neurological Disorders and Stroke of the National Institutes of Health[5R01NS118769] |
| WOS研究方向 | Allergy ; Immunology |
| 语种 | 英语 |
| 出版者 | MOSBY-ELSEVIER |
| WOS记录号 | WOS:001039645600001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306824]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Feng, Jing; Duan, Bo |
| 作者单位 | 1.Univ Michigan, Dept Mol Cellular & Dev Biol, Ann Arbor, MI USA 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Neurol & Psychiat Res & Drug Discovery, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China 5.1105 N Univ Ave, Ann Arbor, MI 48109 USA |
| 推荐引用方式 GB/T 7714 | Feng, Jing,Duan, Bo. Understanding neural mechanisms of mechanical itch[J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY,2023,152(1):32-35. |
| APA | Feng, Jing,&Duan, Bo.(2023).Understanding neural mechanisms of mechanical itch.JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY,152(1),32-35. |
| MLA | Feng, Jing,et al."Understanding neural mechanisms of mechanical itch".JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 152.1(2023):32-35. |
入库方式： OAI收割
来源：上海药物研究所
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