Functional ProTracer identifies patterns of cell proliferation in tissues and underlying regulatory mechanisms
文献类型：期刊论文
| Author | Liu, Xiuxiu3; Han, Maoying3; Weng, Wendong3; Li, Yan3,4,5; Pu, Wenjuan3; Liu, Kuo6; Li, Xufeng6; He, Lingjuan7; Sun, Ruilin1; Shen, Ruling2 |
| Source | NPJ REGENERATIVE MEDICINE
 |
| Issued Date | 2023-08-03 |
| Volume | 8Issue:1Pages:7 |
| DOI | 10.1038/s41536-023-00318-y |
| Corresponding Author | Zhou, Bin(zhoubin@sibs.ac.cn) |
| English Abstract | A genetic system, ProTracer, has been recently developed to record cell proliferation in vivo. However, the ProTracer is initiated by an infrequently used recombinase Dre, which limits its broad application for functional studies employing floxed gene alleles. Here we generated Cre-activated functional ProTracer (fProTracer) mice, which enable simultaneous recording of cell proliferation and tissue-specific gene deletion, facilitating broad functional analysis of cell proliferation by any Cre driver. |
| Funding Project | National Science Foundation of China[82088101] ; National Science Foundation of China[32050087] ; National Science Foundation of China[32100592] ; National Science Foundation of China[32170848] ; National Science Foundation of China[32100585] ; National Science Foundation of China[32100648] ; National Key Research amp; Development Program of China[2019YFA0802000] ; National Key Research amp; Development Program of China[2019YFA0110403] ; National Key Research amp; Development Program of China[2022YFA104200] ; CAS Project for Young Scientists in Basic Research[YSBR-012] ; Youth Innovation Promotion Association CAS, Shanghai Pilot Program for Basic Research-CAS, Shanghai Branch[JCYJ-SHFY-2021-0] ; Program for Guangdong Introduction Innovative and Entrepreneurial Teams[2017ZT07S347] ; New Cornerstone Science Foundation through the New Cornerstone Investigator Program ; Shanghai Municipal Science and Technology Major Project |
| WOS Research Area | Cell Biology ; Engineering |
| Language | 英语 |
| WOS ID | WOS:001042110200001 |
| Publisher | NATURE PORTFOLIO |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306848]  |
| Collection | 新药研究国家重点实验室 |
| Corresponding Author | Zhou, Bin |
| Affiliation | 1.Shanghai Model Organisms Ctr Inc, Shanghai, Peoples R China 2.Shanghai Lab Anim Res Ctr, Shanghai, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Ctr Excellence Mol Cell Sci, New Cornerstone Sci Lab,Univ Chinese Acad Sci, Shanghai, Peoples R China 4.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai, Shandong, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China 6.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Life Sci, Key Lab Syst Hlth Sci Zhejiang Prov, Hangzhou, Peoples R China 7.Westlake Univ Sch Life Sci, Hangzhou, Peoples R China 8.Soochow Univ, Collaborat Innovat Ctr Hematol, Cam Su Genom Resources Ctr, State Key Lab Radiat Med & Protect,Cyrus Tang Hema, Suzhou, Peoples R China 9.Tongji Univ, Shanghai East Hosp, State Key Lab Cardiol, Sch Med, Shanghai, Peoples R China 10.AstraZeneca, Res & Early Dev, Cardiovasc Renal & Metab CVRM, BioPharmaceut R&D,Biosci Cardiovasc, Gothenburg, Sweden |
| Recommended Citation GB/T 7714 | Liu, Xiuxiu,Han, Maoying,Weng, Wendong,et al. Functional ProTracer identifies patterns of cell proliferation in tissues and underlying regulatory mechanisms[J]. NPJ REGENERATIVE MEDICINE,2023,8(1):7. |
| APA | Liu, Xiuxiu.,Han, Maoying.,Weng, Wendong.,Li, Yan.,Pu, Wenjuan.,...&Zhou, Bin.(2023).Functional ProTracer identifies patterns of cell proliferation in tissues and underlying regulatory mechanisms.NPJ REGENERATIVE MEDICINE,8(1),7. |
| MLA | Liu, Xiuxiu,et al."Functional ProTracer identifies patterns of cell proliferation in tissues and underlying regulatory mechanisms".NPJ REGENERATIVE MEDICINE 8.1(2023):7. |
入库方式： OAI收割
来源：上海药物研究所
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