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Functional ProTracer identifies patterns of cell proliferation in tissues and underlying regulatory mechanisms

文献类型：期刊论文

作者Liu, Xiuxiu3; Han, Maoying3; Weng, Wendong3; Li, Yan3,4,5; Pu, Wenjuan3; Liu, Kuo6; Li, Xufeng6; He, Lingjuan7; Sun, Ruilin1; Shen, Ruling2
刊名NPJ REGENERATIVE MEDICINE
出版日期2023-08-03
卷号8期号:1页码:7
DOI10.1038/s41536-023-00318-y
通讯作者Zhou, Bin(zhoubin@sibs.ac.cn)
英文摘要A genetic system, ProTracer, has been recently developed to record cell proliferation in vivo. However, the ProTracer is initiated by an infrequently used recombinase Dre, which limits its broad application for functional studies employing floxed gene alleles. Here we generated Cre-activated functional ProTracer (fProTracer) mice, which enable simultaneous recording of cell proliferation and tissue-specific gene deletion, facilitating broad functional analysis of cell proliferation by any Cre driver.
资助项目National Science Foundation of China[82088101] ; National Science Foundation of China[32050087] ; National Science Foundation of China[32100592] ; National Science Foundation of China[32170848] ; National Science Foundation of China[32100585] ; National Science Foundation of China[32100648] ; National Key Research amp; Development Program of China[2019YFA0802000] ; National Key Research amp; Development Program of China[2019YFA0110403] ; National Key Research amp; Development Program of China[2022YFA104200] ; CAS Project for Young Scientists in Basic Research[YSBR-012] ; Youth Innovation Promotion Association CAS, Shanghai Pilot Program for Basic Research-CAS, Shanghai Branch[JCYJ-SHFY-2021-0] ; Program for Guangdong Introduction Innovative and Entrepreneurial Teams[2017ZT07S347] ; New Cornerstone Science Foundation through the New Cornerstone Investigator Program ; Shanghai Municipal Science and Technology Major Project
WOS研究方向Cell Biology ; Engineering
语种英语
WOS记录号WOS:001042110200001
出版者NATURE PORTFOLIO
源URL[http://119.78.100.183/handle/2S10ELR8/306848]  
专题新药研究国家重点实验室
通讯作者Zhou, Bin
作者单位1.Shanghai Model Organisms Ctr Inc, Shanghai, Peoples R China
2.Shanghai Lab Anim Res Ctr, Shanghai, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Ctr Excellence Mol Cell Sci, New Cornerstone Sci Lab,Univ Chinese Acad Sci, Shanghai, Peoples R China
4.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai, Shandong, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China
6.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Life Sci, Key Lab Syst Hlth Sci Zhejiang Prov, Hangzhou, Peoples R China
7.Westlake Univ Sch Life Sci, Hangzhou, Peoples R China
8.Soochow Univ, Collaborat Innovat Ctr Hematol, Cam Su Genom Resources Ctr, State Key Lab Radiat Med & Protect,Cyrus Tang Hema, Suzhou, Peoples R China
9.Tongji Univ, Shanghai East Hosp, State Key Lab Cardiol, Sch Med, Shanghai, Peoples R China
10.AstraZeneca, Res & Early Dev, Cardiovasc Renal & Metab CVRM, BioPharmaceut R&D,Biosci Cardiovasc, Gothenburg, Sweden
推荐引用方式
GB/T 7714		 Liu, Xiuxiu,Han, Maoying,Weng, Wendong,et al. Functional ProTracer identifies patterns of cell proliferation in tissues and underlying regulatory mechanisms[J]. NPJ REGENERATIVE MEDICINE,2023,8(1):7.
APA Liu, Xiuxiu.,Han, Maoying.,Weng, Wendong.,Li, Yan.,Pu, Wenjuan.,...&Zhou, Bin.(2023).Functional ProTracer identifies patterns of cell proliferation in tissues and underlying regulatory mechanisms.NPJ REGENERATIVE MEDICINE,8(1),7.
MLA Liu, Xiuxiu,et al."Functional ProTracer identifies patterns of cell proliferation in tissues and underlying regulatory mechanisms".NPJ REGENERATIVE MEDICINE 8.1(2023):7.

入库方式： OAI收割

来源：上海药物研究所

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