Proteomics of adjacent-to-tumor samples uncovers clinically relevant biological events in hepatocellular carcinoma
文献类型：期刊论文
| 作者 | Zhu, Hongwen1,2; Lin, Youpei3,4; Lu, Dayun2,5; Wang, Shisheng6,7; Liu, Yuejia5; Dong, Liangqing3,4; Meng, Qian1,2; Gao, Jing1,2; Wang, Yuqiu1,2; Song, Nixue1,2 |
| 刊名 | NATIONAL SCIENCE REVIEW
 |
| 出版日期 | 2023-06-28 |
| 卷号 | 10期号:8页码:17 |
| ISSN号 | 2095-5138 |
| 关键词 | proteomics hepatocellular carcinoma normal tissue adjacent to tumor heterogeneity |
| DOI | 10.1093/nsr/nwad167 |
| 通讯作者 | Zhu, Hongwen(zhw@simm.ac.cn) ; Gao, Qiang(gaoqiang@fudan.edu.cn) ; Zhou, Hu(zhouhu@simm.ac.cn) |
| 英文摘要 | Normal adjacent tissues (NATs) of hepatocellular carcinoma (HCC) differ from healthy liver tissues and their heterogeneity may contain biological information associated with disease occurrence and clinical outcome that has yet to be fully evaluated at the proteomic level. This study provides a detailed description of the heterogeneity of NATs and the differences between NATs and healthy livers and revealed that molecular features of tumor subgroups in HCC were partially reflected in their respective NATs. Proteomic data classified HCC NATs into two subtypes (Subtypes 1 and 2), and Subtype 2 was associated with poor prognosis and high-risk recurrence. The pathway and immune features of these two subtypes were characterized. Proteomic differences between the two NAT subtypes and healthy liver tissues were further investigated using data-independent acquisition mass spectrometry, revealing the early molecular alterations associated with the progression from healthy livers to NATs. This study provides a high-quality resource for HCC researchers and clinicians and may significantly expand the knowledge of tumor NATs to eventually benefit clinical practice. |
| WOS关键词 | INTEGRATED PROTEOGENOMIC CHARACTERIZATION ; SOMATIC MUTATIONS ; CANCER ; LIVER ; CELLS ; LANDSCAPE ; REVEALS ; PROGRESSION ; EXPRESSION ; DYNAMICS |
| 资助项目 | National Key Research and Development Program of China[2020YFA0509000] ; Shanghai Science and Technology Commission[20YF1457300] ; Youth Innovation Promotion Association CAS[2022285] ; SANOFI Scholarship Program ; Program of Shanghai Young Academic Research Leader from the Science and Technology Commission of Shanghai Municipality[20XD1424900] ; Shanghai Municipal Science and Technology Major Project |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| 出版者 | OXFORD UNIV PRESS |
| WOS记录号 | WOS:001046219400001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306863]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhu, Hongwen; Gao, Qiang; Zhou, Hu |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Analyt Chem, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China 3.Fudan Univ, Zhongshan Hosp, Liver Canc Inst, Dept Liver Surg & Transplantat, Shanghai 200032, Peoples R China 4.Fudan Univ, Key Lab Carcinogenesis & Canc Invas, Minist Educ, Shanghai 200032, Peoples R China 5.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China 6.Sichuan Univ, West China Hosp, Inst Syst Genet, Chengdu 610041, Peoples R China 7.Sichuan Univ, West China Hosp, Sichuan Prov Engn Lab Pathol Clin Applicat, NHC Key Lab Transplant Engn & Immunol, Chengdu 610041, Peoples R China 8.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 9.Washington Univ, McDonnell Genome Inst, Siteman Canc Ctr, Dept Med, St Louis, MI 63108 USA 10.Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA |
| 推荐引用方式 GB/T 7714 | Zhu, Hongwen,Lin, Youpei,Lu, Dayun,et al. Proteomics of adjacent-to-tumor samples uncovers clinically relevant biological events in hepatocellular carcinoma[J]. NATIONAL SCIENCE REVIEW,2023,10(8):17. |
| APA | Zhu, Hongwen.,Lin, Youpei.,Lu, Dayun.,Wang, Shisheng.,Liu, Yuejia.,...&Zhou, Hu.(2023).Proteomics of adjacent-to-tumor samples uncovers clinically relevant biological events in hepatocellular carcinoma.NATIONAL SCIENCE REVIEW,10(8),17. |
| MLA | Zhu, Hongwen,et al."Proteomics of adjacent-to-tumor samples uncovers clinically relevant biological events in hepatocellular carcinoma".NATIONAL SCIENCE REVIEW 10.8(2023):17. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。