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Advances in Structure Pharmaceutics from Discovery to Evaluation and Design

文献类型：期刊论文

作者Xu, Huipeng1,2; Wu, Li1,3,4; Xue, Yanling5; Yang, Ting1; Xiong, Ting1; Wang, Caifen1; He, Siyu1,2; Sun, Hongyu1; Cao, Zeying1,2; Liu, Jun1
刊名MOLECULAR PHARMACEUTICS
出版日期2023-08-08
页码26
ISSN号1543-8384
关键词structure pharmaceutics drug delivery systems three-dimension quality evaluation structuredesign
DOI10.1021/acs.molpharmaceut.3c00514
通讯作者Naeem, Abid(anaeemktk@gmail.com) ; Yin, Xianzhen(xzyin@lglab.ac.cn) ; Zhang, Jiwen(jwzhang@simm.ac.cn)
英文摘要Drug delivery systems (DDSs) play an important role indeliveringactive pharmaceutical ingredients (APIs) to targeted sites with apredesigned release pattern. The chemical and biological propertiesof APIs and excipients have been extensively studied for their contributionto DDS quality and effectiveness; however, the structural characteristicsof DDSs have not been adequately explored. Structure pharmaceuticsinvolves the study of the structure of DDSs, especially the three-dimensional(3D) structures, and its interaction with the physiological and pathologicalstructure of organisms, possibly influencing their release kineticsand targeting abilities. A systematic overview of the structures ofa variety of dosage forms, such as tablets, granules, pellets, microspheres,powders, and nanoparticles, is presented. Moreover, the influenceof structures on the release and targeting capability of DDSs hasalso been discussed, especially the in vitro and in vivo release correlation and the structure-based organ-and tumor-targeting capabilities of particles with different structures.Additionally, an in-depth discussion is provided regarding the applicationof structural strategies in the DDSs design and evaluation. Furthermore,some of the most frequently used characterization techniques in structurepharmaceutics are briefly described along with their potential futureapplications.
WOS关键词MESOPOROUS SILICA NANOPARTICLES ; X-RAY MICROTOMOGRAPHY ; CONTROLLED-RELEASE KINETICS ; OSMOTIC PUMP TABLETS ; IN-VIVO CORRELATIONS ; DRY POWDER INHALERS ; DRUG-DELIVERY ; BIOMEDICAL APPLICATIONS ; GOLD NANOPARTICLES ; DENSITY VARIATIONS
资助项目National Natural Science Foundation of China[82273863] ; Open Project of Key Laboratory of Modern Preparation of Traditional Chinese Medicine of Ministry of Education of Jiangxi University of Chinese Medicine[zdsys-202102] ; Innovation Leading Talents Short-term Program of Jiangxi Province, China[1262000102]
WOS研究方向Research & Experimental Medicine ; Pharmacology & Pharmacy
语种英语
出版者AMER CHEMICAL SOC
WOS记录号WOS:001043705900001
源URL[http://119.78.100.183/handle/2S10ELR8/306866]  
专题中国科学院上海药物研究所
通讯作者Naeem, Abid; Yin, Xianzhen; Zhang, Jiwen
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201203, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Yantai Univ, Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat, Minist Educ, Yantai 264005, Peoples R China
4.Jiangxi Univ Chinese Med, Key Lab Modern Preparat Tradit Chinese Med, Minist Educ, Nanchang 330004, Peoples R China
5.Chinese Acad Sci, Shanghai Adv Res Inst, Shanghai Synchrotron Radiat Facil, Shanghai 201204, Peoples R China
6.Natl Inst Food & Drug Control, NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipie, Beijing 100050, Peoples R China
7.Lingang Lab, Shanghai 201602, Peoples R China
推荐引用方式
GB/T 7714		 Xu, Huipeng,Wu, Li,Xue, Yanling,et al. Advances in Structure Pharmaceutics from Discovery to Evaluation and Design[J]. MOLECULAR PHARMACEUTICS,2023:26.
APA Xu, Huipeng.,Wu, Li.,Xue, Yanling.,Yang, Ting.,Xiong, Ting.,...&Zhang, Jiwen.(2023).Advances in Structure Pharmaceutics from Discovery to Evaluation and Design.MOLECULAR PHARMACEUTICS,26.
MLA Xu, Huipeng,et al."Advances in Structure Pharmaceutics from Discovery to Evaluation and Design".MOLECULAR PHARMACEUTICS (2023):26.

入库方式： OAI收割

来源：上海药物研究所

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