Ent- kaurane diterpenoids from Isodon japonica var. glaucocalyx with PCSK9 inhibitory activities
文献类型：期刊论文
| 作者 | Wang, Ge1,2; Chen, Tong1,3; Guo, Peng-Ju1,4; Peng, Shou1,2; Wang, Wen-Qiong1,2; Xuan, Li-Jiang1,2
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| 刊名 | PHYTOCHEMISTRY LETTERS
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| 出版日期 | 2023-10-01 |
| 卷号 | 57页码:56-61 |
| 关键词 | Purine-diterpenoid derivatives Ent -kaurane diterpenoid PCSK9 inhibition activity |
| ISSN号 | 1874-3900 |
| DOI | 10.1016/j.phytol.2023.07.012 |
| 通讯作者 | Wang, Wen-Qiong(wenqiong1019@simm.ac.cn) ; Xuan, Li-Jiang(ljxuan@simm.ac.cn) |
| 英文摘要 | Three new (glaucocalyxin L-N, 1-3) and six known ent-kauranoids (4-9) were isolated from the aerial part of Isodon japonica var. glaucocalyx. Compounds 1 and 2 are ent-kaurane-type diterpenoids with an adenine group. The structures of the isolated compounds were established using NMR and MS measurements and the absolute configuration of compound 3 was determined using experimental and calculated electronic circular dichroism spectra. Compounds 6 and 8 showed relatively remarkable inhibitory activities on proprotein convertase subtilisin/kexin 9 (PCSK9) expression at 20 & mu;M. |
| WOS关键词 | CONSTITUENTS ; PATHWAY |
| 资助项目 | State Key Laboratory of Drug Research[SIMM1601ZZ-03] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001048086600001 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306878]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Wang, Wen-Qiong; Xuan, Li-Jiang |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210029, Peoples R China 4.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Ge,Chen, Tong,Guo, Peng-Ju,et al. Ent- kaurane diterpenoids from Isodon japonica var. glaucocalyx with PCSK9 inhibitory activities[J]. PHYTOCHEMISTRY LETTERS,2023,57:56-61. |
| APA | Wang, Ge,Chen, Tong,Guo, Peng-Ju,Peng, Shou,Wang, Wen-Qiong,&Xuan, Li-Jiang.(2023).Ent- kaurane diterpenoids from Isodon japonica var. glaucocalyx with PCSK9 inhibitory activities.PHYTOCHEMISTRY LETTERS,57,56-61. |
| MLA | Wang, Ge,et al."Ent- kaurane diterpenoids from Isodon japonica var. glaucocalyx with PCSK9 inhibitory activities".PHYTOCHEMISTRY LETTERS 57(2023):56-61. |
入库方式： OAI收割
来源：上海药物研究所
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