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Cross-scale tracing of nanoparticles and tumors at the single-cell level using the whole-lung atlas

文献类型：期刊论文

作者Cao, Zeying1,3; Zhao, Yanli2; Sun, Hongyu1; Sun, Xian4; Zhang, Yu4; Zhang, Shuo2; Wang, Caifen1; Xiong, Ting1,5; Naeem, Abid6; Zhang, Jiwen1,3,5,6,7
刊名SCIENCE ADVANCES
出版日期2023-08-01
卷号9期号:31页码:14
ISSN号2375-2548
DOI10.1126/sciadv.adh7779
通讯作者Zhang, Jiwen(xzyin@lglab.ac.cn) ; Yin, Xianzhen(jwzhang@simm.ac.cn)
英文摘要Currently, the effectiveness of oncotherapy is limited by tumor heterogeneities, which presents a huge challenge for the development of nanotargeted drug delivery systems (DDSs). Therefore, it is important to resolve the spatiotemporal interactions between tumors and nanoparticles. However, targeting evaluation has been limited by particle visualization due to the gap between whole-organ scale and subcellular precision. Here, a high-precision three-dimensional (3D) visualization of tumor structure based on the micro-optical sectioning tomography (MOST) system and fluorescence MOST (fMOST) system is presented to clarify 3D spatial distribution of nanoparticles within the tumor. We demonstrate that through the MOST/fMOST system, it is possible to reveal multidimensional and cross-scale correlations between the tumor structure and nanoparticle distribution to remodel the tumor microenvironment and explore the structural parameters of vasculature. This visualization methodology provides an accurate assessment of the efficacy, distribution, and targeting efficiency of DDSs for oncotherapy compared to available approaches.
WOS关键词BLOOD-VESSELS ; VASCULATURE ; THERAPY ; SYSTEM
资助项目National Key Ramp;D Program of China[2020YFE0201700] ; Lingang Laboratory[LG-QS-202206-04] ; Innovation Leading Talents Short-term Program of Jiangxi Province, China[1262000102]
WOS研究方向Science & Technology - Other Topics
语种英语
出版者AMER ASSOC ADVANCEMENT SCIENCE
WOS记录号WOS:001041633500020
源URL[http://119.78.100.183/handle/2S10ELR8/306902]  
专题中国科学院上海药物研究所
通讯作者Zhang, Jiwen; Yin, Xianzhen
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201203, Peoples R China
2.Lingang Lab, Shanghai 201602, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr MOST & Image Fus Anal, Shanghai 201210, Peoples R China
5.Shenyang Pharmaceut Univ, Coll Pharm, Shenyang 110016, Peoples R China
6.Jiangxi Univ Tradit Chinese Med, Key Lab Modern Preparat TCM, Minist Educ, Nanchang 330004, Peoples R China
7.Natl Inst Food & Drug Control, NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipie, Beijing 100050, Peoples R China
推荐引用方式
GB/T 7714		 Cao, Zeying,Zhao, Yanli,Sun, Hongyu,et al. Cross-scale tracing of nanoparticles and tumors at the single-cell level using the whole-lung atlas[J]. SCIENCE ADVANCES,2023,9(31):14.
APA Cao, Zeying.,Zhao, Yanli.,Sun, Hongyu.,Sun, Xian.,Zhang, Yu.,...&Yin, Xianzhen.(2023).Cross-scale tracing of nanoparticles and tumors at the single-cell level using the whole-lung atlas.SCIENCE ADVANCES,9(31),14.
MLA Cao, Zeying,et al."Cross-scale tracing of nanoparticles and tumors at the single-cell level using the whole-lung atlas".SCIENCE ADVANCES 9.31(2023):14.

入库方式： OAI收割

来源：上海药物研究所

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