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B-seco Limonoids with anti-inflammatory activity from Tetradium fraxinifolium (Hook.) TGHartley

文献类型：期刊论文

作者Jiang, Yu-Xia1,2; Yao, Jia-Ying3,4; Qin, Nan2,5; Tan, Jun-Jie2; Han, Feng1,2; Qu, Shi-Jin2; He, Shi-Jun4,7; Tan, Chang-Heng1,2,5,6
刊名FITOTERAPIA
出版日期2023-09-01
卷号169页码:6
关键词Tetradium fraxinifolium Rutaceae seco limonoids Anti-inflammation RAW264 7 cells
ISSN号0367-326X
DOI10.1016/j.fitote.2023.105606
通讯作者He, Shi-Jun(heshijun@shutcm.edu.cn) ; Tan, Chang-Heng(chtan@simm.ac.cn)
英文摘要Fraxinifolines A-F (1-6), six new B-seco limonoids, together with four known A,D-di-seco ones, were isolated from the twigs with leaves of Tetradium fraxinifolium. Their structures with absolute configurations were elucidated on the basis of analysis of MS, NMR, single-crystal X-ray diffraction and biogenetic pathway. An anti-inflammatory bioassay in vitro showed limonoids 1-3 had significant immunosuppressive effect against the production of proinflammatory cytokines (IL-1 & beta; and/or TNF-& alpha;) in lipopolysaccharide (LPS)-stimulated RAW264.7 cells.
资助项目NationalScience amp; Technology Major Project Key New Drug Creation and Manufacturing Program of the National Health Commission of China[2019ZX09201001]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:001042808900001
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/306905]  
专题中国科学院上海药物研究所
通讯作者He, Shi-Jun; Tan, Chang-Heng
作者单位1.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Res Ctr, Shanghai 201203, Peoples R China
3.Jiangxi Univ Chinese Med, Grad Sch, Nanchang 330004, Peoples R China
4.Shanghai Univ Tradit Chinese Med, Innovat Res Inst Tradit Chinese Med, 1200 Cailun Rd, Shanghai 201203, Peoples R China
5.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China
6.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
7.Shanghai Univ Tradit Chinese Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Jiang, Yu-Xia,Yao, Jia-Ying,Qin, Nan,et al. B-seco Limonoids with anti-inflammatory activity from Tetradium fraxinifolium (Hook.) TGHartley[J]. FITOTERAPIA,2023,169:6.
APA Jiang, Yu-Xia.,Yao, Jia-Ying.,Qin, Nan.,Tan, Jun-Jie.,Han, Feng.,...&Tan, Chang-Heng.(2023).B-seco Limonoids with anti-inflammatory activity from Tetradium fraxinifolium (Hook.) TGHartley.FITOTERAPIA,169,6.
MLA Jiang, Yu-Xia,et al."B-seco Limonoids with anti-inflammatory activity from Tetradium fraxinifolium (Hook.) TGHartley".FITOTERAPIA 169(2023):6.

入库方式： OAI收割

来源：上海药物研究所

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