The in vivo drug delivery pattern of the organelle-targeting small molecules
文献类型：期刊论文
| 作者 | Fang, Zhao1; Chen, Hao1,2 |
| 刊名 | ADVANCED DRUG DELIVERY REVIEWS
 |
| 出版日期 | 2023-09-01 |
| 卷号 | 200页码:14 |
| ISSN号 | 0169-409X |
| 关键词 | Organelle-targeting In vivo imaging Small molecular probe Biodistribution Subcellular structure Human disease |
| DOI | 10.1016/j.addr.2023.115020 |
| 通讯作者 | Chen, Hao(haoc@simm.ac.cn) |
| 英文摘要 | Eukaryotic cell organelles sustain the life of cells. Their structural changes and dysfunctions can cause abnormal physiological activities and lead to various diseases. Molecular imaging technology enables the visualization of subcellular structures, cells, organs, and the whole living body's structure and metabolism dynamic changes. This could help to reveal the pharmacology mechanisms and drug delivery pathway in vivo. This article discusses the relationship between organelles and human disease, reviews recent probes targeting organelles and their behavior in vivo. We found that mitochondria-targeting probes prefer accumulation in the intestine, heart, and tumor. The lysosome-targeting probe accumulates in the intestine and tumor. Few studies on endoplasmic reticulum- or Golgi apparatus-targeting probes have been reported for in vivo imaging. We hope this review could provide new insights for developing and applying organelle-targeting probes. |
| WOS关键词 | ENDOPLASMIC-RETICULUM STRESS ; F-18-FLUOROBENZYL TRIPHENYL PHOSPHONIUM ; DELOCALIZED LIPOPHILIC CATIONS ; MITOCHONDRIAL DYSFUNCTION ; FLUORESCENT-PROBES ; AXONAL-TRANSPORT ; LYSOSOME ; BIOGENESIS ; STORAGE ; DISEASE |
| 资助项目 | National Science and Technology Innovation 2030 Major Project of China[2021ZD0203900] ; Shanghai Municipal Science and Technology Major Project ; National Natural Science Foundation of China[LG-QS-202206-01] ; Lingang Laboratory ; [82071976] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | ELSEVIER |
| WOS记录号 | WOS:001051713100001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306917]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Chen, Hao |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Chem Biol, Shanghai 201203, Peoples R China 2.4th Floor,Bldg 3,647 Songtao Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fang, Zhao,Chen, Hao. The in vivo drug delivery pattern of the organelle-targeting small molecules[J]. ADVANCED DRUG DELIVERY REVIEWS,2023,200:14. |
| APA | Fang, Zhao,&Chen, Hao.(2023).The in vivo drug delivery pattern of the organelle-targeting small molecules.ADVANCED DRUG DELIVERY REVIEWS,200,14. |
| MLA | Fang, Zhao,et al."The in vivo drug delivery pattern of the organelle-targeting small molecules".ADVANCED DRUG DELIVERY REVIEWS 200(2023):14. |
入库方式： OAI收割
来源：上海药物研究所
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