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MiR-552-3p Regulates Multiple Fibrotic and Inflammatory genes Concurrently in Hepatic Stellate Cells Improving NASH-associated Phenotypes

文献类型：期刊论文

作者Ma, Ningning1,2,3; Hou, Aijun1,3; Pan, Xiangyu4; Sun, Fuguang1,3; Xu, Xiaoding; Yu, Chuwei1,3; Lai, Rongtao; Huang, Ruimin1,3; Gong, Likun1,3; Xie, Qing6
刊名INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
出版日期2023
卷号19期号:11页码:3456-3471
关键词MiR-552-3p NASH Fibrosis Inflammation Synergistic multi-target suppression
ISSN号1449-2288
DOI10.7150/ijbs.80760
通讯作者Xie, Qing(xieqingrjh@163.com) ; Chen, Jing(jingchen@simm.ac.cn) ; Ren, Jin(jren@cdser.simm.ac.cn)
英文摘要Non-alcoholic steatohepatitis (NASH) is a chronic liver disease characterized by hepatic steatosis, inflammation, and progressive fibrosis. Our previous study demonstrated that microRNA-552-3p (miR-552-3p) was down-regulated in the livers of patients with NASH and alleviated hepatic glycolipid metabolic disorders. However, whether miR-552-3p affects NASH progression remains unclear. In this current study, we found that hepatic miR-552-3p expression was negatively correlated with the degree of liver fibrosis and inflammation of NASH patients. Interestingly, the level of miR-552-3p was decreased during hepatic stellate cell (HSC) activation in symbolscript Overexpression of miR-552-3p could not only inhibit the expression of fibrotic and inflammatory genes, but also restrain the activation of TGF-& beta;1/Smad3 signaling pathway by down-regulating the expression of symbolscript and symbolscript in HSCs, finally suppressing HSC activation. More importantly, overexpression of miR-552-3p ameliorated liver fibrosis and inflammation in two murine models: high fat/high fructose/high cholesterol diet-induced NASH model and carbon tetrachloride (CCl4)-treated liver fibrosis model. In conclusion, miR-552-3p plays a crucial role in the pathogenesis of NASH by limiting multiple fibrotic and inflammatory pathways in HSCs, which may shed light on its therapeutic potential in NASH.
WOS关键词LIVER FIBROSIS
资助项目Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine[ZYYCXTD-D-202210] ; Foundation of Shanghai Science and Technology Committee[21DZ2291100]
WOS研究方向Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics
语种英语
WOS记录号WOS:001043595000011
出版者IVYSPRING INT PUBL
源URL[http://119.78.100.183/handle/2S10ELR8/306923]  
专题新药研究国家重点实验室
通讯作者Xie, Qing; Chen, Jing; Ren, Jin
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Safety Evaluat & Res, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China
2.ShanghaiTech Univ, Sch Life Sci & Technol, 100 Haike Rd, Shanghai 201210, Peoples R China
3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
4.Soochow Univ, Coll Pharmaceut Sci, Dept Pharmaceut, Suzhou 215123, Peoples R China
5.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
6.Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Infect Dis, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China
推荐引用方式
GB/T 7714		 Ma, Ningning,Hou, Aijun,Pan, Xiangyu,et al. MiR-552-3p Regulates Multiple Fibrotic and Inflammatory genes Concurrently in Hepatic Stellate Cells Improving NASH-associated Phenotypes[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,2023,19(11):3456-3471.
APA Ma, Ningning.,Hou, Aijun.,Pan, Xiangyu.,Sun, Fuguang.,Xu, Xiaoding.,...&Ren, Jin.(2023).MiR-552-3p Regulates Multiple Fibrotic and Inflammatory genes Concurrently in Hepatic Stellate Cells Improving NASH-associated Phenotypes.INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,19(11),3456-3471.
MLA Ma, Ningning,et al."MiR-552-3p Regulates Multiple Fibrotic and Inflammatory genes Concurrently in Hepatic Stellate Cells Improving NASH-associated Phenotypes".INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 19.11(2023):3456-3471.

入库方式： OAI收割

来源：上海药物研究所

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