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Antimicrobial abietane-type diterpenoids from Torreya grandis

文献类型：期刊论文

作者Cui, Jiao-Jiao1,2; Li, Wei-Jia3; Wang, Cheng-Lei2; Huang, Yi-Qi2; Lin, Wei3; Zhou, Bin2; Yue, Jian-Min1,2
刊名PHYTOCHEMISTRY
出版日期2022-09-01
卷号201页码:11
ISSN号0031-9422
关键词Torreya grandis var. merrillii Hu Taxaceae Diterpenoid Abietane Torgranols A-L Antimicrobial activities
DOI10.1016/j.phytochem.2022.113278
通讯作者Zhou, Bin(zbbrush@simm.ac.cn) ; Yue, Jian-Min(jmyue@simm.ac.cn)
英文摘要Twelve undescribed abietane-type diterpenoids, along with ten known analogues were isolated from the twigs and leaves of Torreya grandis var. merrillii Hu. Their structures were characterized by spectroscopic data analyses, single-crystal X-ray diffraction, and ECD spectra. Torgranols A-C possess three different architectures shaped via a common 6,7-seco-procedure and subsequent ring formations. In particular, torgranol A represents the first example of a 6,7-seco-abietane diterpenoid featuring a unique oxygen bridge between C-3 and C-6. The biosynthetic pathways for torgranols A-C were proposed. Some compounds displayed antimicrobial activities against Mycobacterium tuberculosis and/or Staphylococcus aureus.
WOS关键词DIBENZYLBUTYROLACTONE LIGNANS ; CIRCULAR-DICHROISM ; SMALL MOLECULES ; STEM BARK ; NUCIFERA ; ASSIGNMENT ; LABDANE ; LEAVES ; ROOTS ; PULP
资助项目National Natural Science Foundation[22177122] ; National Natural Science Foundation[81861138045] ; Biological Resources Program, CAS of People's Republic of China[KFJ-BRP-008-001] ; Shanghai Pujiang Program[21PJ1416000]
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
语种英语
出版者PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号WOS:001044795400005
源URL[http://119.78.100.183/handle/2S10ELR8/306926]  
专题新药研究国家重点实验室
通讯作者Zhou, Bin; Yue, Jian-Min
作者单位1.Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
3.Nanjing Univ Chinese Med, Sch Med & Holist Integrat Med, Dept Pathogen Biol, Nanjing 210023, Peoples R China
推荐引用方式
GB/T 7714		 Cui, Jiao-Jiao,Li, Wei-Jia,Wang, Cheng-Lei,et al. Antimicrobial abietane-type diterpenoids from Torreya grandis[J]. PHYTOCHEMISTRY,2022,201:11.
APA Cui, Jiao-Jiao.,Li, Wei-Jia.,Wang, Cheng-Lei.,Huang, Yi-Qi.,Lin, Wei.,...&Yue, Jian-Min.(2022).Antimicrobial abietane-type diterpenoids from Torreya grandis.PHYTOCHEMISTRY,201,11.
MLA Cui, Jiao-Jiao,et al."Antimicrobial abietane-type diterpenoids from Torreya grandis".PHYTOCHEMISTRY 201(2022):11.

入库方式： OAI收割

来源：上海药物研究所

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