A novel branched galacturonan from Gardenia jasminoides alleviates liver fibrosis linked to TLR4/NF-kappa B signaling
文献类型：期刊论文
| 作者 | Ma, Xiaonan1,3; Zhou, Wanqi1,2; Nie, Yingmin1,3; Jing, Xiaoqi1; Li, Saijuan1,2; Jin, Can1,2,4; Zhu, Anming1,2; Su, Juan1; Liao, Wenfeng1; Ding, Kan1,2,3,4
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| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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| 出版日期 | 2023-08-01 |
| 卷号 | 245页码:14 |
| ISSN号 | 0141-8130 |
| 关键词 | Polysaccharides Pectin Gardenia jasminoides Liver fibrosis TLR4 NF-kappa B |
| DOI | 10.1016/j.ijbiomac.2023.125540 |
| 通讯作者 | Ding, Kan(dingkan@simm.ac.cn) |
| 英文摘要 | Gardenia jasminoides (GJ) is a classic edible medicine in China of which the fruit has been proved to alleviate liver damage. We hypothesized whether polysaccharide in the fruit could have comparable bioactivity. To address this, a novel polysaccharide GJE0.2-2, is purified from the fruit of Gardenia jasminoides. Indeed, GJE0.2-2 may attenuate CCl4-induced liver fibrosis in mice and impede the expression of critical fibrogenesis associated molecules such as alpha-SMA, FN1, and Collagen I induced by TGF-beta in human hepatic stellate LX-2 cells. Mechanism studies suggest that this bioactivity may be implicated in TLR4/NF-kappa B signaling pathway via directly binding to TLR4. The structure characterization shows that the backbone of this polysaccharide is mainly composed of galacturonic acid with minor rhamnose, branched with galactose and arabinose, galacturonic acid, and esterified hexenuronic acid (HexpA). These findings provide evidence for a novel pectin-linked polysaccharide-based new drug candidate development for liver fibrosis therapy. |
| WOS关键词 | NF-KAPPA-B ; POLYSACCHARIDE ; PECTIN ; INFLAMMATION ; ELUCIDATION ; ACTIVATION ; APOPTOSIS ; INJURY ; L. |
| 资助项目 | Shanghai Municipal Science and Technology Major Project ; Department of Science and Technology of Guangdong Province ; National Natural Science Foundation of China[2019B090904008] ; [31870801] ; [2021B0909050003] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| 语种 | 英语 |
| 出版者 | ELSEVIER |
| WOS记录号 | WOS:001049081200001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306929]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Ding, Kan |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Glycochemistry & Glycobiol Lab, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China 2.Nanjing Univ Chinese Med, Sch Chinese Mat Med, 138 Xianlin Ave, Nanjing 210029, Jiangsu, Peoples R China 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, SSIP Healthcare & Med Demonstrat Zone, Zhongshan 528400, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Xiaonan,Zhou, Wanqi,Nie, Yingmin,et al. A novel branched galacturonan from Gardenia jasminoides alleviates liver fibrosis linked to TLR4/NF-kappa B signaling[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2023,245:14. |
| APA | Ma, Xiaonan.,Zhou, Wanqi.,Nie, Yingmin.,Jing, Xiaoqi.,Li, Saijuan.,...&Ding, Kan.(2023).A novel branched galacturonan from Gardenia jasminoides alleviates liver fibrosis linked to TLR4/NF-kappa B signaling.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,245,14. |
| MLA | Ma, Xiaonan,et al."A novel branched galacturonan from Gardenia jasminoides alleviates liver fibrosis linked to TLR4/NF-kappa B signaling".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 245(2023):14. |
入库方式： OAI收割
来源：上海药物研究所
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