Traditional Chinese Medicine Targeting Sarcoma Virus Oncogene-related Diseases
文献类型：期刊论文
| 作者 | Wang, Yiying1; Wang, Xiaoyu1,2; Su, Kexin1; Yang, Yifu1 |
| 刊名 | CURRENT CANCER DRUG TARGETS
 |
| 出版日期 | 2023 |
| 卷号 | 23期号:10页码:751-763 |
| 关键词 | c-Src natural compounds traditional chinese medicine cancer inflammation osteoblast |
| ISSN号 | 1568-0096 |
| DOI | 10.2174/1568009623666230426093244 |
| 通讯作者 | Wang, Xiaoyu(0000002733@shutcm.edu.cn) |
| 英文摘要 | The sarcoma virus oncogene (Src) tyrosine kinase, a nonreceptor protein-tyrosine kinase, plays a crucial role in cell survival, migration, differentiation and proliferation. The study of Src has developed considerably since it was first discovered as a proto-oncogene. Src has also been associated with inflammation and bone-related diseases. Src inhibitors (bosutinib, ponatinib, dasatinib, and vandetanib) have been put into clinical use. However, their side effects and cardiovascular toxicity may be a concern. There is an urgent need to explore new Src inhibitors. Traditional Chinese medicine (TCM), which has a vast history, can provide a broad resource base. Many natural compounds and TCM extracts have the potential for anti-Src treatment. This article describes the natural compounds and extracts from TCM. |
| WOS关键词 | CELL LUNG-CANCER ; NF-KAPPA-B ; KINASE INHIBITOR SARACATINIB ; SRC FAMILY KINASES ; PHASE-I ; BREAST-CANCER ; URSOLIC ACID ; ANTIINFLAMMATORY ACTIVITIES ; OSTEOCLAST DIFFERENTIATION ; MULTIPLE-MYELOMA |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:001050059700001 |
| 出版者 | BENTHAM SCIENCE PUBL LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306932]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Wang, Xiaoyu |
| 作者单位 | 1.Shanghai Univ Tradit Chinese Med, Expt Ctr Sci & Technol, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yiying,Wang, Xiaoyu,Su, Kexin,et al. Traditional Chinese Medicine Targeting Sarcoma Virus Oncogene-related Diseases[J]. CURRENT CANCER DRUG TARGETS,2023,23(10):751-763. |
| APA | Wang, Yiying,Wang, Xiaoyu,Su, Kexin,&Yang, Yifu.(2023).Traditional Chinese Medicine Targeting Sarcoma Virus Oncogene-related Diseases.CURRENT CANCER DRUG TARGETS,23(10),751-763. |
| MLA | Wang, Yiying,et al."Traditional Chinese Medicine Targeting Sarcoma Virus Oncogene-related Diseases".CURRENT CANCER DRUG TARGETS 23.10(2023):751-763. |
入库方式： OAI收割
来源：上海药物研究所
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