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Cyclodextrin-Coordinated Liposome-in-Gel for Transcutaneous Quercetin Delivery for Psoriasis Treatment

文献类型：期刊论文

作者Zhang, Yuqin1,2; Gong, Shuqing1,2; Liu, Lin1,3; Shen, Huan1,6; Liu, Ergang1; Pan, Li1,2; Gao, Nan1,4; Chen, Rongli1; Huang, Yongzhuo1,2,5,6
刊名ACS APPLIED MATERIALS & INTERFACES
出版日期2023-08-16
页码13
ISSN号1944-8244
关键词quercetin hydroxypropyl-beta-cyclodextrin liposome-in-gel psoriasis percutaneous delivery
DOI10.1021/acsami.3c07582
通讯作者Liu, Ergang(liuergang@zidd.ac.cn) ; Huang, Yongzhuo(yzhuang@simm.ac.cn)
英文摘要Psoriasis is a chronic inflammatory skin disease that is difficult to treat. Quercetin (QT) is a dietary flavonoid known for its antiinflammatory effects and safe use in humans. However, the topical application of quercetin for psoriasis treatment presents a significant challenge due to its poor water solubility and low stability in semisolid preparations, where it tends to recrystallize. This work presents a novel liposome-in-gel formulation for the quercetin-based topical treatment of psoriasis. The quercetin-loading liposomes are stabilized by hydroxypropyl-beta-cyclodextrin (HPCD), which interacts with phospholipids via hydrogen bonding to form a layer of an HPCD coating on the liposome interface, thus resulting in improved stability. Various analytical techniques, such as FTIR spectroscopy, Raman spectroscopy, and TEM, were used to characterize the molecular coordination patterns between cyclodextrin and liposomes. The results demonstrated that HPCD assisted the liposomes in interfacing with the matrix lipids and keratins of the stratum corneum, thereby enhancing skin permeability and promoting drug penetration and retention in the skin. The in vivo results showed that the topical QT HPCD-liposome-in-gel improved the treatment efficacy of psoriatic plaque compared to free QT. It alleviated the symptoms of skin thickening and downregulated proinflammatory cytokines, including TNF-alpha, IL-17A, and IL-1 beta. The results suggested that the HPCD-coordinated liposome-in-gel system could be a stable carrier for topical QT therapy with good potential in psoriasis treatment.
WOS关键词TRANSDERMAL DELIVERY ; LIPID ORGANIZATION ; DRUG ; SKIN ; PERMEATION ; STABILITY ; 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN ; NANOPARTICLES ; ENCAPSULATION ; PATHOGENESIS
资助项目National Key Research and Development Program of China[2021YFE0103100] ; National Key Research and Development Program of China[2021YFC2400600] ; National Natural Science Foundation of China[81925035] ; Department of Science and Technology of Guangdong Province[2019B090904008] ; Department of Science and Technology of Guangdong Province[2021B0909050003] ; Zhongshan Municipal Bureau of Science and Technology[LJ2021001] ; Zhongshan Municipal Bureau of Science and Technology[CXTD2022011]
WOS研究方向Science & Technology - Other Topics ; Materials Science
语种英语
出版者AMER CHEMICAL SOC
WOS记录号WOS:001049968900001
源URL[http://119.78.100.183/handle/2S10ELR8/306971]  
专题新药研究国家重点实验室
通讯作者Liu, Ergang; Huang, Yongzhuo
作者单位1.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China
2.Zunyi Med Univ, Sch Pharm, Zunyi 563003, Peoples R China
3.Southern Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Peoples R China
4.Guizhou Med Univ, Sch Pharm, Guiyang 550025, Guizhou, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
6.NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipie, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Yuqin,Gong, Shuqing,Liu, Lin,et al. Cyclodextrin-Coordinated Liposome-in-Gel for Transcutaneous Quercetin Delivery for Psoriasis Treatment[J]. ACS APPLIED MATERIALS & INTERFACES,2023:13.
APA Zhang, Yuqin.,Gong, Shuqing.,Liu, Lin.,Shen, Huan.,Liu, Ergang.,...&Huang, Yongzhuo.(2023).Cyclodextrin-Coordinated Liposome-in-Gel for Transcutaneous Quercetin Delivery for Psoriasis Treatment.ACS APPLIED MATERIALS & INTERFACES,13.
MLA Zhang, Yuqin,et al."Cyclodextrin-Coordinated Liposome-in-Gel for Transcutaneous Quercetin Delivery for Psoriasis Treatment".ACS APPLIED MATERIALS & INTERFACES (2023):13.

入库方式： OAI收割

来源：上海药物研究所

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