中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 新药研究国家重点实验室
Combining gut microbiota modulation and chemotherapy by capecitabine-loaded prebiotic nanoparticle improves colorectal cancer therapy

文献类型：期刊论文

作者Lang, Tianqun1,2,3; Zhu, Runqi1,2,4; Zhu, Xiao1,2,4; Yan, Wenlu1,2,4; Li, Yu5; Zhai, Yihui1,2,4; Wu, Ting6; Huang, Xin1,2,4; Yin, Qi1,2,3,4; Li, Yaping1,2,3,4,5,7
刊名NATURE COMMUNICATIONS
出版日期2023-08-07
卷号14期号:1页码:16
DOI10.1038/s41467-023-40439-y
通讯作者Yin, Qi(qyin@simm.ac.cn) ; Li, Yaping(ypli@simm.ac.cn)
英文摘要Colorectal cancer (CRC) therapy efficiency can be influenced by the microbiota in the gastrointestinal tract. Compared with traditional intervention, prebiotics delivery into the gut is a more controllable method for gut microbiota modulatory therapy. Capecitabine (Cap), the first-line chemotherapeutic agent for CRC, lacks a carrier that can prolong its half-life. Here, we construct a Cap-loaded nanoparticle using the prebiotic xylan-stearic acid conjugate (SCXN). The oral administration of SCXN delays the drug clearance in the blood and increases the intra-tumoral Cap concentration in the CRC mouse model. SCXN also facilitates the probiotic proliferation and short chain fatty acid production. Compared with free Cap, SCXN enhances the anti-tumor immunity and increases the tumor inhibition rate from 5.29 to 71.78%. SCXN exhibits good biocompatibility and prolongs the median survival time of CRC mice from 14 to 33.5 d. This prebiotics-based nanoparticle provides a promising CRC treatment by combining gut microbiota modulation and chemotherapy. Gut microbiota regulates colorectal cancer (CRC) progression and respond to therapy. Here the authors generate nanoparticles using prebiotic micelles and loaded with the chemo drug capecitabine that boost gastrointestinal probiotic response, increase anti-tumour immunity and improve survival when provided orally in CRC preclinical murine models.
WOS关键词CHAIN FATTY-ACIDS ; BUTYRATE FORMATION ; PATHOGENESIS ; FUTURE
资助项目National Key Ramp;D Program of China[2022YFC3401404] ; National Natural Science Foundation of China[32171315] ; National Natural Science Foundation of China[31930066] ; National Natural Science Foundation of China[32130058] ; Natural Science Foundation of Shandong[ZR2019ZD25] ; Science and Technology Innovation Action Plan Sailing Plan of Shanghai[22YF1460500]
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:001045127700003
出版者NATURE PORTFOLIO
源URL[http://119.78.100.183/handle/2S10ELR8/306974]  
专题新药研究国家重点实验室
通讯作者Yin, Qi; Li, Yaping
作者单位1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
3.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
6.Nanjing Med Univ, Sch Pharm, Dept Pharmaceut, Nanjing 211116, Peoples R China
7.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China
推荐引用方式
GB/T 7714		 Lang, Tianqun,Zhu, Runqi,Zhu, Xiao,et al. Combining gut microbiota modulation and chemotherapy by capecitabine-loaded prebiotic nanoparticle improves colorectal cancer therapy[J]. NATURE COMMUNICATIONS,2023,14(1):16.
APA Lang, Tianqun.,Zhu, Runqi.,Zhu, Xiao.,Yan, Wenlu.,Li, Yu.,...&Li, Yaping.(2023).Combining gut microbiota modulation and chemotherapy by capecitabine-loaded prebiotic nanoparticle improves colorectal cancer therapy.NATURE COMMUNICATIONS,14(1),16.
MLA Lang, Tianqun,et al."Combining gut microbiota modulation and chemotherapy by capecitabine-loaded prebiotic nanoparticle improves colorectal cancer therapy".NATURE COMMUNICATIONS 14.1(2023):16.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。