STING agonist-boosted mRNA immunization via intelligent design of nanovaccines for enhancing cancer immunotherapy
文献类型：期刊论文
| 作者 | Zhou, Lei1,3; Yi, Wenzhe1,5; Zhang, Zehong4,5; Shan, Xiaoting1,5; Zhao, Zitong1; Sun, Xiangshi1; Wang, Jue1,5; Wang, Hao3; Jiang, Hualiang4,5 ; Zheng, Mingyue4,5
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| 刊名 | NATIONAL SCIENCE REVIEW
 |
| 出版日期 | 2023-09-04 |
| 卷号 | 10期号:10页码:16 |
| ISSN号 | 2095-5138 |
| 关键词 | vaccine mRNA STING cancer immunotherapy nanoparticles |
| DOI | 10.1093/nsr/nwad214 |
| 通讯作者 | Zheng, Mingyue(myzheng@simm.ac.cn) ; Wang, Dangge(dgwang@shsmu.edu.cn) ; Li, Yaping(ypli@simm.ac.cn) |
| 英文摘要 | Messenger RNA (mRNA) vaccine is revolutionizing the methodology of immunization in cancer. However, mRNA immunization is drastically limited by multistage biological barriers including poor lymphatic transport, rapid clearance, catalytic hydrolysis, insufficient cellular entry and endosome entrapment. Herein, we design a mRNA nanovaccine based on intelligent design to overcome these obstacles. Highly efficient nanovaccines are carried out with machine learning techniques from datasets of various nanocarriers, ensuring successful delivery of mRNA antigen and cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) to targets. It activates stimulator of interferon genes (STING), promotes mRNA-encoded antigen presentation and boosts antitumour immunity in vivo, thus inhibiting tumour growth and ensuring long-term survival of tumour-bearing mice. This work provides a feasible and safe strategy to facilitate STING agonist-synergized mRNA immunization, with great translational potential for enhancing cancer immunotherapy. This paper provides a rational design option to develop mRNA nanovaccine with machine learning techniques, leading to effective stimulator of interferon genes (STING) agonist-synergized mRNA immunization. |
| WOS关键词 | DELIVERY |
| 资助项目 | National Key Ramp;D Program of China[2022YFC3401404] ; National Natural Science Foundation of China[32170935] ; National Natural Science Foundation of China[31930066] ; Youth Innovation Promotion Association of Chinese Academy of Sciences[2019283] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| 出版者 | OXFORD UNIV PRESS |
| WOS记录号 | WOS:001058732500003 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/307019]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zheng, Mingyue; Wang, Dangge; Li, Yaping |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res & Ctr Pharmaceut, Shanghai 201203, Peoples R China 2.Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Precis Res Ctr Refractory Dis, Sch Med, Shanghai 201620, Peoples R China 3.China State Inst Pharmaceut Ind, Shanghai 201203, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China 5.Univeris Chinese Acad Sci, Beijing 100049, Peoples R China 6.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Lei,Yi, Wenzhe,Zhang, Zehong,et al. STING agonist-boosted mRNA immunization via intelligent design of nanovaccines for enhancing cancer immunotherapy[J]. NATIONAL SCIENCE REVIEW,2023,10(10):16. |
| APA | Zhou, Lei.,Yi, Wenzhe.,Zhang, Zehong.,Shan, Xiaoting.,Zhao, Zitong.,...&Li, Yaping.(2023).STING agonist-boosted mRNA immunization via intelligent design of nanovaccines for enhancing cancer immunotherapy.NATIONAL SCIENCE REVIEW,10(10),16. |
| MLA | Zhou, Lei,et al."STING agonist-boosted mRNA immunization via intelligent design of nanovaccines for enhancing cancer immunotherapy".NATIONAL SCIENCE REVIEW 10.10(2023):16. |
入库方式： OAI收割
来源：上海药物研究所
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