A pectic polysaccharide isolated from Achyranthes bidentata is metabolized by human gut Bacteroides spp.
文献类型：期刊论文
| 作者 | Wen, Chang; Li, Tingting1,2; Wang, Binqiang1,2; Jin, Can2; Li, Saijuan2; Li, Yun2; Li, Meixia2; Ding, Kan1,2,3,4,5
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| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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| 出版日期 | 2023-09-01 |
| 卷号 | 248页码:14 |
| ISSN号 | 0141-8130 |
| 关键词 | Achyranthes bidentata Polysaccharides Gut microbiota PULs SCFAs |
| DOI | 10.1016/j.ijbiomac.2023.125785 |
| 通讯作者 | Li, Meixia(limei@simm.ac.cn) ; Ding, Kan(dingkan@simm.ac.cn) |
| 英文摘要 | Achyranthes bidentata (A. bidentata) is a famous traditional Chinese medicine (TGM) for treatment osteoporosis. Polysaccharides, a major factor for shaping the gut microbiota, are the primary ingredients of A. bidentata. However, bioactivity of A. bidentata polysaccharide on human gut microbiota (HGM) remains unknown. Here, a homogeneous pectic polysaccharide A23-1 with average molecular weight of 93.085 kDa was extracted and purified from A. bidentata. And A23-1 was compsed of rhamnose, glucuronic acid, galacturonic acid, glucose, galactose and arabinose in a molar ratio of 7.26: 0.76: 5.12: 2.54: 23.51: 60.81. GC-MS, partial acid hydrolysis and NMR results indicated the backbone of A23-1 was composed of 1, 2, 4-Rhap and 1, 4-GlapA, while the branches were composed of galactose, arabinose, glucose and glucuronic acid. Further, A23-1 was found to be degraded into monosaccharides and fragments. Taking Bacteroides thetaiotaomicron (BT) as a model, we suggested three polysaccharide utilization loci (PULs) might be involved in the A23-1 degradation. Degraded products generated by BO might not support the growth of probiotics. Besides, acetate and propionate as the main end products were generated by Bacteroides spp. and probiotics utilizing A23-1. These findings suggested A23-1 was possible one of food sources of human gut Bacteroides spp. |
| WOS关键词 | CHAIN FATTY-ACIDS ; STRUCTURAL-CHARACTERIZATION ; MICROBIOTA ; BACTERIA ; OSTEOPOROSIS ; BIOACTIVITY ; FIBER ; BUTYRATE ; IMMUNITY ; L. |
| 资助项目 | National Key Research and Development Program of China[32271332] ; National Natural Science Foundation of China[31870801] ; National Natural Science Foundation of China[2019B090904008] ; High-level New Ramp;D Institute from Department of Science and Technology of Guangdong Province[2021B0909050003] ; High-level Innovative Research Institute from Department of Science and Technology of Guangdong Province ; Zhongshan Municipal Bureau of Science and Technology ; Shanghai Municipal Science and Technology Major Project ; [2022YFA1303802] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| 语种 | 英语 |
| 出版者 | ELSEVIER |
| WOS记录号 | WOS:001056080400001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/307022]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Li, Meixia; Ding, Kan |
| 作者单位 | 1.Zunyi Med Univ, Sch Pharm, 201 Dalian Rd, Zunyi 563003, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, State Key Lab Drug Res,Glycochem & Glycobiol Lab, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China 5.Henan Univ Chinese Med, Acad Chinese Med Sci, Henan Polysaccharide Res Ctr, Zhengzhou 450046, Henan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wen, Chang,Li, Tingting,Wang, Binqiang,et al. A pectic polysaccharide isolated from Achyranthes bidentata is metabolized by human gut Bacteroides spp.[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2023,248:14. |
| APA | Wen, Chang.,Li, Tingting.,Wang, Binqiang.,Jin, Can.,Li, Saijuan.,...&Ding, Kan.(2023).A pectic polysaccharide isolated from Achyranthes bidentata is metabolized by human gut Bacteroides spp..INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,248,14. |
| MLA | Wen, Chang,et al."A pectic polysaccharide isolated from Achyranthes bidentata is metabolized by human gut Bacteroides spp.".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 248(2023):14. |
入库方式： OAI收割
来源：上海药物研究所
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