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Prelimbic cortex dynorphin/& kappa; opioid receptor system modulates methamphetamine-induced cognitive impairment

文献类型：期刊论文

作者Cheng, Ying-jie1; Deng, Ying-zhi1; Deng, Di1; Wu, Man-qing1; Chai, Jing-rui2; Wang, Yu-jun2; Liu, Jing-gen2,5; Zhao, Min1,3,4
刊名ADDICTION BIOLOGY
出版日期2023-09-01
卷号28期号:9页码:12
ISSN号1355-6215
关键词cognitive impairment dynorphin methamphetamine prelimbic cortex & kappa opioid receptor
DOI10.1111/adb.13323
通讯作者Liu, Jing-gen(jgliu@simm.ac.cn) ; Zhao, Min(drminzhao@smhc.org.cn)
英文摘要Chronic exposure to methamphetamine (METH) causes severe and persistent cognitive impairment. The present study aimed to investigate the role of dynorphin/? opioid receptor (KOR) system in the development of METH-induced cognitive impairment. We found that mice showed significant cognitive impairment in the novel object recognition test (NOR) following daily injections of METH (10 mg/kg) for seven consecutive days. Systemic blockade of KOR prevented METH-induced cognitive impairment by pretreatment of the selective KOR antagonist norBNI (10 mg/kg, i.p.) or KOR deletion. Then, significant increased dynorphin and KOR mRNA were observed exclusively in prelimbic cortex (PL) other than infralimbic cortex. Finally, microinjection with norBNI into PL also improved cognitive memory in METH-treated mice using NOR and spontaneous alternation behaviour test. Our results demonstrated that dynorphin/KOR system activation in PL may be a possible mechanism for METH-induced cognitive impairment and shed light on KOR antagonists as a potential neuroprotective agent against the cognitive deficits induced by drug abuse.
WOS关键词PREFRONTAL CORTEX ; NUCLEUS-ACCUMBENS ; STRUCTURAL ABNORMALITIES ; RAT ; SEEKING ; GLUTAMATE ; RELEASE ; BRAIN ; REINSTATEMENT ; ENHANCEMENT
资助项目National Nature Science Foundation[82130041] ; Shanghai Clinical Research Center for Mental Health[19MC1911100] ; Shanghai Engineering Research Center of Intelligent Addiction Treatment and Rehabilitation[19DZ2255200] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX05] ; Shanghai Shenkang Hospital Development Center[SHDC2020CR3045B] ; Lingang Lab[LG202106-03-01]
WOS研究方向Biochemistry & Molecular Biology ; Substance Abuse
语种英语
出版者WILEY
WOS记录号WOS:001052757600001
源URL[http://119.78.100.183/handle/2S10ELR8/307028]  
专题中国科学院上海药物研究所
通讯作者Liu, Jing-gen; Zhao, Min
作者单位1.Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Sch Med, Shanghai, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai, Peoples R China
3.Shanghai Key Lab Psychot Disorders, Shanghai, Peoples R China
4.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techno, Shanghai, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Cheng, Ying-jie,Deng, Ying-zhi,Deng, Di,et al. Prelimbic cortex dynorphin/& kappa; opioid receptor system modulates methamphetamine-induced cognitive impairment[J]. ADDICTION BIOLOGY,2023,28(9):12.
APA Cheng, Ying-jie.,Deng, Ying-zhi.,Deng, Di.,Wu, Man-qing.,Chai, Jing-rui.,...&Zhao, Min.(2023).Prelimbic cortex dynorphin/& kappa; opioid receptor system modulates methamphetamine-induced cognitive impairment.ADDICTION BIOLOGY,28(9),12.
MLA Cheng, Ying-jie,et al."Prelimbic cortex dynorphin/& kappa; opioid receptor system modulates methamphetamine-induced cognitive impairment".ADDICTION BIOLOGY 28.9(2023):12.

入库方式： OAI收割

来源：上海药物研究所

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