Synthesis and characterization of heterotelechelic poly(ethylene glycol)s with amino acid at one end and hydroxyl group at another end
文献类型：期刊论文
| 作者 | Zhang, Jing1,2; Su, Zhi-Guo1; Ma, Guang-Hui1 |
| 刊名 | JOURNAL OF APPLIED POLYMER SCIENCE
 |
| 出版日期 | 2008-11-15 |
| 卷号 | 110期号:4页码:2432-2439 |
| 关键词 | polyethers ring-opening polymerization crosslinking |
| ISSN号 | 0021-8995 |
| 其他题名 | J. Appl. Polym. Sci. |
| 中文摘要 | Heterotelechelic poly(ethylene glycol)s are widely used in the modification, conjugation, and crosslinking of biomacromolecules. A series of heterotelechelic PEGs with amino acid at one end and hydroxyl group at another end, including alpha-glycine-omega-hydroxyl-PEG, alpha-proline-omega-hydroxyl-PEG, and alpha-phenylalanine-omega-hydroxyl-PEG, were first synthesized in this study. The reaction proceeded at ambient temperature under alkaline conditions via an aqueous solution polymerization of ethylene oxide. Amino group of glycine, proline, and phenylalanine was the initiating center in the polymerizations, and carboxyl group of these amino acids was reserved as one of the active end groups of the obtained heterotelechelic PEG. Purification of the desired products was accomplished by silica gel column chromatography. The obtained heterotelechelic PEGs were characterized by means of FT-IR, H-1 NMR, C-13 NMR, MS, and RP-HPLC. They were in different forms depending on the type of initiating amino acid, e.g. alpha-glycine-omega-hydroxyl-PEG and alpha-phenylalanine-omega-hydroxyl-PEG are in branched form, and alpha-proline-omega-hydroxyl-PEG is linear. Amino acids were conjugated to PEG chains through the stable carbon-nitrogen bond. Compared with the traditional critical polymerization conditions, the advantage of this method is that various amino acid ended heterotelechelic PEGs can be designed and obtained by using different amino acid as the initiator through a much more convenient route, which proceeded in aqueous solution at ambient temperature. (C) 2008 Wiley Periodicals, Inc. |
| 英文摘要 | Heterotelechelic poly(ethylene glycol)s are widely used in the modification, conjugation, and crosslinking of biomacromolecules. A series of heterotelechelic PEGs with amino acid at one end and hydroxyl group at another end, including alpha-glycine-omega-hydroxyl-PEG, alpha-proline-omega-hydroxyl-PEG, and alpha-phenylalanine-omega-hydroxyl-PEG, were first synthesized in this study. The reaction proceeded at ambient temperature under alkaline conditions via an aqueous solution polymerization of ethylene oxide. Amino group of glycine, proline, and phenylalanine was the initiating center in the polymerizations, and carboxyl group of these amino acids was reserved as one of the active end groups of the obtained heterotelechelic PEG. Purification of the desired products was accomplished by silica gel column chromatography. The obtained heterotelechelic PEGs were characterized by means of FT-IR, H-1 NMR, C-13 NMR, MS, and RP-HPLC. They were in different forms depending on the type of initiating amino acid, e.g. alpha-glycine-omega-hydroxyl-PEG and alpha-phenylalanine-omega-hydroxyl-PEG are in branched form, and alpha-proline-omega-hydroxyl-PEG is linear. Amino acids were conjugated to PEG chains through the stable carbon-nitrogen bond. Compared with the traditional critical polymerization conditions, the advantage of this method is that various amino acid ended heterotelechelic PEGs can be designed and obtained by using different amino acid as the initiator through a much more convenient route, which proceeded in aqueous solution at ambient temperature. (C) 2008 Wiley Periodicals, Inc. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Polymer Science |
| 研究领域[WOS] | Polymer Science |
| 关键词[WOS] | ANIONIC-POLYMERIZATION ; PYRIDYL DISULFIDE ; OXIDE) ; DERIVATIVES ; NANOSHELLS ; INITIATOR ; THERAPY ; SURFACE ; CANCER |
| 收录类别 | SCI |
| 原文出处 | |
| 语种 | 英语 |
| WOS记录号 | WOS:000259755300066 |
| 公开日期 | 2013-10-08 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/2911]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Jing,Su, Zhi-Guo,Ma, Guang-Hui. Synthesis and characterization of heterotelechelic poly(ethylene glycol)s with amino acid at one end and hydroxyl group at another end[J]. JOURNAL OF APPLIED POLYMER SCIENCE,2008,110(4):2432-2439. |
| APA | Zhang, Jing,Su, Zhi-Guo,&Ma, Guang-Hui.(2008).Synthesis and characterization of heterotelechelic poly(ethylene glycol)s with amino acid at one end and hydroxyl group at another end.JOURNAL OF APPLIED POLYMER SCIENCE,110(4),2432-2439. |
| MLA | Zhang, Jing,et al."Synthesis and characterization of heterotelechelic poly(ethylene glycol)s with amino acid at one end and hydroxyl group at another end".JOURNAL OF APPLIED POLYMER SCIENCE 110.4(2008):2432-2439. |
入库方式： OAI收割
来源：过程工程研究所
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