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Human genetic history on the Tibetan Plateau in the past 5100 years

文献类型：期刊论文

作者Wang, Hongru1,17; Yang, Melinda A.16,17; Wangdue, Shargan15; Lu, Hongliang13,14; Chen, Honghai12; Li, Linhui15; Dong, Guanghui11; Tsring, Tinley15; Yuan, Haibing13,14; He, Wei15
刊名SCIENCE ADVANCES
出版日期2023-03-17
卷号9期号:11页码:18
ISSN号2375-2548
DOI10.1126/sciadv.add5582
通讯作者Fu, Qiaomei(fuqiaomei@ivpp.ac.cn)
英文摘要Using genome-wide data of 89 ancient individuals dated to 5100 to 100 years before the present (B.P.) from 29 sites across the Tibetan Plateau, we found plateau-specific ancestry across plateau populations, with substantial genetic structure indicating high differentiation before 2500 B.P. Northeastern plateau populations rapidly showed admixture associated with millet farmers by 4700 B.P. in the Gonghe Basin. High genetic similarity on the southern and southwestern plateau showed population expansion along the Yarlung Tsangpo River since 3400 years ago. Central and southeastern plateau populations revealed extensive genetic admixture within the plateau historically, with substantial ancestry related to that found in southern and southwestern plateau populations. Over the past similar to 700 years, substantial gene flow from lowland East Asia further shaped the genetic landscape of present-day plateau populations. The high-altitude adaptive EPAS1 allele was found in plateau populations as early as in a 5100-year-old individual and showed a sharp increase over the past 2800 years.
WOS关键词PERMANENT HUMAN OCCUPATION ; ANCIENT HUMAN GENOMES ; SKIN PIGMENTATION ; HUMAN SETTLEMENT ; HUMAN-EVOLUTION ; EYE COLOR ; SEQUENCE ; HAIR ; VARIANT ; IDENTIFICATION
资助项目National Key R&D Program of China ; Chinese Academy of Sciences (CAS) ; National Natural Science Foundation of China[2021YFC1523600] ; Shanghai Qi Zhi Institute[YSBR-019] ; Shanghai Qi Zhi Institute[XDB26000000] ; Tencent Foundation through the XPLORER PRIZE[41925009] ; Tencent Foundation through the XPLORER PRIZE[32030020] ; Howard Hughes Medical Institute ; Key National Social Science Foundation of China ; Basic Science Center Program[55008731] ; Shanghai Municipal Science and Technology Major Project[16ZDA144] ; [32288101] ; [2017SHZDZX01]
WOS研究方向Science & Technology - Other Topics
语种英语
出版者AMER ASSOC ADVANCEMENT SCIENCE
WOS记录号WOS:000969832000005
资助机构National Key R&D Program of China ; Chinese Academy of Sciences (CAS) ; National Natural Science Foundation of China ; Shanghai Qi Zhi Institute ; Tencent Foundation through the XPLORER PRIZE ; Howard Hughes Medical Institute ; Key National Social Science Foundation of China ; Basic Science Center Program ; Shanghai Municipal Science and Technology Major Project
源URL[http://119.78.100.205/handle/311034/22501]  
专题中国科学院古脊椎动物与古人类研究所
通讯作者Fu, Qiaomei
作者单位1.Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Shenzhen 518120, Peoples R China
2.Shanghai Qi Zhi Inst, Shanghai 200232, Peoples R China
3.Fudan Univ, Key Lab Contemporary Anthropol, Minist Educ, Shanghai 201203, Peoples R China
4.Fudan Univ, Human Phenome Inst, Zhangjiang Fudan Int Innovat Ctr, Shanghai 201203, Peoples R China
5.Fudan Univ, Zhongshan Hosp, Liver Canc Inst, Dept Liver Surg & Transplantat, Shanghai 200032, Peoples R China
6.Univ Calif Merced, Dept Anthropol & Heritage Studies, Merced, CA 95343 USA
7.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Nutr & Hlth, Key Lab Computat Biol, Shanghai 200031, Peoples R China
8.Fudan Univ, Ctr Evolutionary Biol, Collaborat Innovat Ctr Genet & Dev, Sch Life Sci,State Key Lab Genet Engn, Shanghai 200438, Peoples R China
9.Peking Univ, Sch Archaeol & Museol, Beijing 100871, Peoples R China
10.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Hongru,Yang, Melinda A.,Wangdue, Shargan,et al. Human genetic history on the Tibetan Plateau in the past 5100 years[J]. SCIENCE ADVANCES,2023,9(11):18.
APA Wang, Hongru.,Yang, Melinda A..,Wangdue, Shargan.,Lu, Hongliang.,Chen, Honghai.,...&Fu, Qiaomei.(2023).Human genetic history on the Tibetan Plateau in the past 5100 years.SCIENCE ADVANCES,9(11),18.
MLA Wang, Hongru,et al."Human genetic history on the Tibetan Plateau in the past 5100 years".SCIENCE ADVANCES 9.11(2023):18.

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