Size distribution and lung-deposition of ambient particulate matter oxidative potential: A contrast between dithiothreitol and ascorbic acid assays
文献类型：期刊论文
| 作者 | Famiyeh, Lord1,2; Jia, Chunrong3; Chen, Ke2; Tang, Yu-Ting4; Ji, Dongsheng5; He, Jun2,6; Guo, Qingjun1 |
| 刊名 | ENVIRONMENTAL POLLUTION
 |
| 出版日期 | 2023-11-01 |
| 卷号 | 336页码:13 |
| ISSN号 | 0269-7491 |
| 关键词 | Size distribution Particulate matter Oxidative potential MPPD Lung-deposition Dithiothreitol Ascorbic acid |
| DOI | 10.1016/j.envpol.2023.122437 |
| 通讯作者 | He, Jun(Jun.He@nottingham.edu.cn) |
| 英文摘要 | Particulate matter (PM) inhaled into human lungs causes oxidative stress and adverse health effects through antioxidant depletion (oxidative potential, OP). However, there is limited knowledge regarding the association between the lung-deposited dose (LDD) of PM and OP in extrathoracic (ET), tracheobronchial (TB), and pulmonary (P) regions of human lungs. Dithiothreitol (DTT) and ascorbic acid (AA) assays were employed to measure the OP of PM size fractions to investigate OP distribution in human lungs and identify the chemical drivers. Quasi-ultrafine particles (quasi-UFP, <= 0.49 mu m) exhibited high OP deposition in the TB and P regions, while coarse particles (CP, >= 3.0 mu m) dominated in the ET region. A plot of extrinsic (per air volume) and intrinsic (per PM mass) OP versus LDD revealed that the OP for fine and coarse particles was greatest in the ET region, whereas the OP of quasi-UFP was greatest in alveoli. The study also demonstrated that extrinsic OP and PM doses are not strongly related. The decline in OP with increasing PM dose reveals the need for further investigation of the antagonistic effects of the chemical compositions. Overall, the results presented herein help address the gap in knowledge regarding the association between the OP and LDD of ambient particles in specific regions of human lungs. |
| WOS关键词 | INDUSTRIAL-AREA ; PM2.5 ; PARTICLES ; URBAN ; AIR ; COMPONENTS ; POLLUTION ; METALS ; RISK |
| 资助项目 | Ningbo Science and Technology Innovation (2025) Key Project[2022Z028] ; Ningbo Municipal Commonweal Key Program[2019C910033] ; Ningbo Natural Science Foundation[2023J024] ; National Natural Science Foundation of China[41975831] ; National Natural Science Foundation of China[41625006] ; National Natural Science Foundation of China[41761144066] ; National Natural Science Foundation of China[41561144005] ; National Key Research and Development Program of China[2017YFC0212703] |
| WOS研究方向 | Environmental Sciences & Ecology |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCI LTD |
| WOS记录号 | WOS:001076525000001 |
| 资助机构 | Ningbo Science and Technology Innovation (2025) Key Project ; Ningbo Municipal Commonweal Key Program ; Ningbo Natural Science Foundation ; National Natural Science Foundation of China ; National Key Research and Development Program of China |
| 源URL | [http://ir.igsnrr.ac.cn/handle/311030/198348]  |
| 专题 | 中国科学院地理科学与资源研究所 |
| 通讯作者 | He, Jun |
| 作者单位 | 1.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, Ctr Environm Remediat, Beijing 100101, Peoples R China 2.Univ Nottingham Ningbo China, Dept Chem & Environm Engn, 199 Taikang E Rd, Ningbo 315100, Peoples R China 3.Univ Memphis, Sch Publ Hlth, Memphis, TN 38152 USA 4.Univ Nottingham Ningbo China, Sch Geog Sci, 199 Taikang E Rd, Ningbo 315100, Peoples R China 5.Chinese Acad Sci, Inst Atmospher Phys, State Kay Lab Atmospher Boundary Layer Phys & Atmo, Beijing 100029, Peoples R China 6.Nottingham Ningbo China Beacon Excellence Res & In, Ningbo 315100, Peoples R China |
| 推荐引用方式 GB/T 7714 | Famiyeh, Lord,Jia, Chunrong,Chen, Ke,et al. Size distribution and lung-deposition of ambient particulate matter oxidative potential: A contrast between dithiothreitol and ascorbic acid assays[J]. ENVIRONMENTAL POLLUTION,2023,336:13. |
| APA | Famiyeh, Lord.,Jia, Chunrong.,Chen, Ke.,Tang, Yu-Ting.,Ji, Dongsheng.,...&Guo, Qingjun.(2023).Size distribution and lung-deposition of ambient particulate matter oxidative potential: A contrast between dithiothreitol and ascorbic acid assays.ENVIRONMENTAL POLLUTION,336,13. |
| MLA | Famiyeh, Lord,et al."Size distribution and lung-deposition of ambient particulate matter oxidative potential: A contrast between dithiothreitol and ascorbic acid assays".ENVIRONMENTAL POLLUTION 336(2023):13. |
入库方式： OAI收割
来源：地理科学与资源研究所
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