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Heritability of cerebral blood flow in adolescent and young adult twins: an arterial spin labeling perfusion imaging study

文献类型：期刊论文

作者Dang, Yi9; He, Yuwen6,7,8; Zheng, Dang5,8; Wang, Xiaoming8; Chen, Jie4; Zhou, Yuan1,2,3,8,9
刊名CEREBRAL CORTEX
出版日期2023-08-23
页码10
ISSN号1047-3211
关键词adolescent and young adults arterial spin labeling cerebral blood flow heritability twin study
DOI10.1093/cercor/bhad310
通讯作者Zhou, Yuan(zhouyuan@psych.ac.cn)
英文摘要Blood perfusion is a fundamental physiological property of all organs and is closely linked to brain metabolism. Genetic factors were reported to have important influences on cerebral blood flow. However, the profile of genetic contributions to cerebral blood flow in adolescents or young adults was underexplored. In this study, we recruited a sample of 65 pairs of same-sex adolescent or young adult twins undergoing resting arterial spin labeling imaging to conduct heritability analyses. Our findings indicate that genetic factors modestly affect cerebral blood flow in adolescents or young adults in the territories of left anterior cerebral artery and right posterior cerebral artery, with the primary contribution being to the frontal regions, cingulate gyrus, and striatum, suggesting a profile of genetic contributions to specific brain regions. Notably, the regions in the left hemisphere demonstrate the highest heritability in most regions examined. These results expand our knowledge of the genetic basis of cerebral blood flow in the developing brain and emphasize the importance of regional analysis in understanding the heritability of cerebral blood flow. Such insights may contribute to our understanding of the underlying genetic mechanism of brain functions and altered cerebral blood flow observed in youths with brain disorders.
收录类别SCI
WOS关键词RESTING-STATE ; OXIDATIVE-METABOLISM ; NORMAL VALUES ; BRAIN ; MRI ; CORTEX ; AGE ; LATERALIZATION ; OPTIMIZATION ; CONNECTIVITY
资助项目The authors thank Ming Song at Institute of Automation, Chinese Academy of Sciences, for his suggestion on ASL sequence. The authors also thank Jie Zhang and other staff members of the Beijing Twin Study at the Institute of Psychology, Chinese Academy of S
WOS研究方向Neurosciences & Neurology
语种英语
出版者OXFORD UNIV PRESS INC
WOS记录号WOS:001077072500001
资助机构The authors thank Ming Song at Institute of Automation, Chinese Academy of Sciences, for his suggestion on ASL sequence. The authors also thank Jie Zhang and other staff members of the Beijing Twin Study at the Institute of Psychology, Chinese Academy of S
源URL[http://ir.psych.ac.cn/handle/311026/46116]  
专题心理研究所_中国科学院心理健康重点实验室
心理研究所_中国科学院行为科学重点实验室
通讯作者Zhou, Yuan
作者单位1.Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China
2.Capital Med Univ, Beijing Anding Hosp, Natl Clin Res Ctr Mental Disorders, Beijing 100029, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing 100101, Peoples R China
4.Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
5.China Natl Childrens Ctr, Beijing 100035, Peoples R China
6.Univ Macau, Fac Hlth Sci, Dept Publ Hlth & Med Adm, Macau 999078, Peoples R China
7.Univ Macau, Ctr Cognit & Brain Sci, Macau 999078, Peoples R China
8.Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China
9.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714		 Dang, Yi,He, Yuwen,Zheng, Dang,et al. Heritability of cerebral blood flow in adolescent and young adult twins: an arterial spin labeling perfusion imaging study[J]. CEREBRAL CORTEX,2023:10.
APA Dang, Yi,He, Yuwen,Zheng, Dang,Wang, Xiaoming,Chen, Jie,&Zhou, Yuan.(2023).Heritability of cerebral blood flow in adolescent and young adult twins: an arterial spin labeling perfusion imaging study.CEREBRAL CORTEX,10.
MLA Dang, Yi,et al."Heritability of cerebral blood flow in adolescent and young adult twins: an arterial spin labeling perfusion imaging study".CEREBRAL CORTEX (2023):10.

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来源：心理研究所

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