Brain network integration underpins differential susceptibility of adolescent anxiety
文献类型：期刊论文
| 作者 | Ding, Qingwen6,7 ; Xu, Jiahua4,5; Peng, Siya2,3; Chen, Jie6,7; Luo, Yu6,7; Li, Xuebing6,7; Wu, Ruilin1; Li, Xinying6,7; Qin, Shaozheng2,3,5
|
| 刊名 | PSYCHOLOGICAL MEDICINE
 |
| 出版日期 | 2023-10-02 |
| 页码 | 10 |
| ISSN号 | 0033-2917 |
| 关键词 | Adolescent anxiety neural susceptibility brain network |
| DOI | 10.1017/S0033291723002325 |
| 通讯作者 | Li, Xinying(lixy@psych.ac.cn) |
| 英文摘要 | BackgroundParenting is a common and potent environmental factor influencing adolescent anxiety. Yet, the underlying neurobiological susceptibility signatures remain elusive. Here, we used a longitudinal twin neuroimaging study to investigate the brain network integration and its heritable relation to underpin the neural differential susceptibility of adolescent anxiety to parenting environments.Methods216 twins from the Beijing Twin Study completed the parenting and anxiety assessments and fMRI scanning. We first identified the brain network integration involved in the influences of parenting at age 12 on anxiety symptoms at age 15. We then estimated to what extent heritable sensitive factors are responsible for the susceptibility of brain network integration.ResultsConsistent with the differential susceptibility theory, the results showed that hypo-connectivity within the central executive network amplified the impact of maternal hostility on anxiety symptoms. A high anti-correlation between the anterior salience and default mode networks played a similar modulatory role in the susceptibility of adolescent anxiety to paternal hostility. Genetic influences (21.18%) were observed for the connectivity pattern in the central executive network.ConclusionsBrain network integration served as a promising neurobiological signature of the differential susceptibility to adolescent anxiety. Our findings deepen the understanding of the neural sensitivity in the developing brain and can inform early identification and personalized interventions for adolescents at risk of anxiety disorders. |
| 收录类别 | SCI |
| WOS关键词 | AMYGDALA-PREFRONTAL CIRCUITRY ; BDNF VAL66MET ; INTERNALIZING SYMPTOMS ; DEPRESSIVE SYMPTOMS ; MENTAL-DISORDERS ; DEFAULT MODE ; STRESS ; POLYMORPHISM ; ENVIRONMENT ; SENSITIVITY |
| 资助项目 | We thank all the twins, families, and schools for making this work possible. We wish to acknowledge Dr Xiaoyu Bai and Dr Lei Hao for their suggestions on analyzing the samples. |
| WOS研究方向 | Psychology ; Psychiatry |
| 语种 | 英语 |
| 出版者 | CAMBRIDGE UNIV PRESS |
| WOS记录号 | WOS:001075271600001 |
| 资助机构 | We thank all the twins, families, and schools for making this work possible. We wish to acknowledge Dr Xiaoyu Bai and Dr Lei Hao for their suggestions on analyzing the samples. |
| 源URL | [http://ir.psych.ac.cn/handle/311026/46134]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Li, Xinying |
| 作者单位 | 1.Beihang Univ, Inst Psychol, Beihang, Peoples R China 2.Beijing Normal Univ, Beijing Key Lab Brain Imaging & Connect, Beijing, Peoples R China 3.Beijing Normal Univ, McGovern Inst Brain Res, IDG State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China 4.Max Planck Univ Coll London, Ctr Comp Psychiat & Ageing Res, London, England 5.Chinese Inst Brain Res, Beijing, Peoples R China 6.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 7.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ding, Qingwen,Xu, Jiahua,Peng, Siya,et al. Brain network integration underpins differential susceptibility of adolescent anxiety[J]. PSYCHOLOGICAL MEDICINE,2023:10. |
| APA | Ding, Qingwen.,Xu, Jiahua.,Peng, Siya.,Chen, Jie.,Luo, Yu.,...&Qin, Shaozheng.(2023).Brain network integration underpins differential susceptibility of adolescent anxiety.PSYCHOLOGICAL MEDICINE,10. |
| MLA | Ding, Qingwen,et al."Brain network integration underpins differential susceptibility of adolescent anxiety".PSYCHOLOGICAL MEDICINE (2023):10. |
入库方式： OAI收割
来源：心理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。