中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 心理研究所
  3. 中国科学院心理研究所
  4. 中国科学院心理健康重点实验室
Pain-preferential thalamocortical neural dynamics across species

文献类型：期刊论文

作者Tu, Yiheng1,2; Li, Zhenjiang1,2; Zhang, Libo1,2; Zhang, Huijuan1,2; Bi, Yanzhi1,2; Yue, Lupeng1,2; Hu, Li1,2
刊名NATURE HUMAN BEHAVIOUR
出版日期2023-10-09
页码22
ISSN号2397-3374
DOI10.1038/s41562-023-01714-6
通讯作者Tu, Yiheng(yihengtu@gmail.com) ; Hu, Li(huli@psych.ac.cn)
英文摘要Searching for pain-preferential neural activity is essential for understanding and managing pain. Here, we investigated the preferential role of thalamocortical neural dynamics in encoding pain using human neuroimaging and rat electrophysiology across three studies. In study 1, we found that painful stimuli preferentially activated the medial-dorsal (MD) thalamic nucleus and its functional connectivity with the dorsal anterior cingulate cortex (dACC) and insula in two human functional magnetic resonance imaging (fMRI) datasets (n = 399 and n = 25). In study 2, human fMRI and electroencephalography fusion analyses (n = 220) revealed that pain-preferential MD responses were identified 89-295 ms after painful stimuli. In study 3, rat electrophysiology further showed that painful stimuli preferentially activated MD neurons and MD-ACC connectivity. These converging cross-species findings provided evidence for pain-preferential thalamocortical neural dynamics, which could guide future pain evaluation and management strategies. Tu et al. show that the medial-dorsal thalamic nucleus and its connectivity with the anterior cingulate cortex preferentially encode pain in humans and rats.
收录类别SCI
WOS关键词PERCEPTION ; MECHANISMS ; RESPONSES ; SYSTEM ; MATRIX ; SPACE
资助项目Y.T. is supported by STI2030-Major Projects by the Ministry of Science and Technology of China (grant no. 2022ZD0206400), National Natural Science Foundation of China (grant nos. 32171078 and 32322035), Scientific Foundation of the Institute of Psychology,[2022ZD0206400] ; STI2030-Major Projects by the Ministry of Science and Technology of China[32071061] ; National Natural Science Foundation of China[E0CX52] ; National Natural Science Foundation of China[E2CX4015] ; Scientific Foundation of the Institute of Psychology, Chinese Academy of Sciences[E1KX0210] ; Young Elite Scientist Sponsorship Program by the China Association for Science and Technology[JQ22018] ; Beijing Natural Science Foundation
WOS研究方向Psychology ; Science & Technology - Other Topics ; Neurosciences & Neurology
语种英语
WOS记录号WOS:001081313800002
出版者NATURE PORTFOLIO
资助机构Y.T. is supported by STI2030-Major Projects by the Ministry of Science and Technology of China (grant no. 2022ZD0206400), National Natural Science Foundation of China (grant nos. 32171078 and 32322035), Scientific Foundation of the Institute of Psychology, ; STI2030-Major Projects by the Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Scientific Foundation of the Institute of Psychology, Chinese Academy of Sciences ; Young Elite Scientist Sponsorship Program by the China Association for Science and Technology ; Beijing Natural Science Foundation
源URL[http://ir.psych.ac.cn/handle/311026/46193]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Tu, Yiheng; Hu, Li
作者单位1.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Tu, Yiheng,Li, Zhenjiang,Zhang, Libo,et al. Pain-preferential thalamocortical neural dynamics across species[J]. NATURE HUMAN BEHAVIOUR,2023:22.
APA Tu, Yiheng.,Li, Zhenjiang.,Zhang, Libo.,Zhang, Huijuan.,Bi, Yanzhi.,...&Hu, Li.(2023).Pain-preferential thalamocortical neural dynamics across species.NATURE HUMAN BEHAVIOUR,22.
MLA Tu, Yiheng,et al."Pain-preferential thalamocortical neural dynamics across species".NATURE HUMAN BEHAVIOUR (2023):22.

入库方式： OAI收割

来源：心理研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。