Association between cognitive function and IL-18 levels in schizophrenia: Dependent on IL18-607 A/C polymorphism
文献类型：期刊论文
| 作者 | Guan, Xiaoni4; Leng, Wanchun3; Hu, Qiongyue3; Xiu, Meihong4; Zhang, Xiangyang1,2
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| 刊名 | PSYCHONEUROENDOCRINOLOGY
 |
| 出版日期 | 2023-12-01 |
| 卷号 | 158页码:6 |
| ISSN号 | 0306-4530 |
| 关键词 | Schizophrenia Cognitive function 607 A/C polymorphism IL-18 |
| DOI | 10.1016/j.psyneuen.2023.106386 |
| 通讯作者 | Zhang, Xiangyang(zhangxy9@gmail.com) |
| 英文摘要 | Accumulating evidence suggests that immune system dysregulation is associated with debilitating neuro-development in schizophrenia (SZ). Cognitive impairment is a persistent feature that occurs during the onset of SZ and persists throughout the course of the disease. Early studies have found that elevated interleukin (IL)-18 interacts with IL18 polymorphism and is correlated with psychotic symptoms in SZ. This study aimed to investigate whether elevated IL-18 levels interacted with the-607 A/C polymorphism to determine cognitive decline in patients with chronic SZ. We recruited 693 inpatients and 422 healthy controls to measure IL-18 levels and genotype the -607 A/C polymorphism. Further, cognitive function was measured by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). We found that IL-18 serum levels were higher in patients than those in healthy controls, and were not associated with IL18 -607 A/C in combined subjects or either patients or healthy controls, respectively. Moreover, -607 A/C was correlated with the visuospatial/ constructional index only in the patients. In addition, our research found that IL-18 levels were positively correlated to immediate memory only in patients with the C/C genotype, but not in patients with C/A or A/A genotype. This study suggests that the relationship of IL-18 with cognitive function depends on the IL18 -607 A/ C polymorphism of SZ patients. |
| 收录类别 | SCI |
| WOS关键词 | IMMUNE-SYSTEM ; INTERLEUKIN-18 LEVELS ; CYTOKINE ALTERATIONS ; INFLAMMATION ; PROMOTER ; BRAIN ; IMPAIRMENT ; SYMPTOMS ; MODEL |
| WOS研究方向 | Endocrinology & Metabolism ; Neurosciences & Neurology ; Psychiatry |
| 语种 | 英语 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| WOS记录号 | WOS:001081232500001 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/46205]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Zhang, Xiangyang |
| 作者单位 | 1.16 Lincui Rd, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 3.Qingdao Mental Hlth Ctr, Qingdao, Peoples R China 4.Peking Univ, Beijing Huilongguan Hosp, Huilongguan Clin Med Sch, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guan, Xiaoni,Leng, Wanchun,Hu, Qiongyue,et al. Association between cognitive function and IL-18 levels in schizophrenia: Dependent on IL18-607 A/C polymorphism[J]. PSYCHONEUROENDOCRINOLOGY,2023,158:6. |
| APA | Guan, Xiaoni,Leng, Wanchun,Hu, Qiongyue,Xiu, Meihong,&Zhang, Xiangyang.(2023).Association between cognitive function and IL-18 levels in schizophrenia: Dependent on IL18-607 A/C polymorphism.PSYCHONEUROENDOCRINOLOGY,158,6. |
| MLA | Guan, Xiaoni,et al."Association between cognitive function and IL-18 levels in schizophrenia: Dependent on IL18-607 A/C polymorphism".PSYCHONEUROENDOCRINOLOGY 158(2023):6. |
入库方式： OAI收割
来源：心理研究所
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