Covariation of preadult environmental exposures, adult brain imaging phenotypes, and adult personality traits
文献类型：期刊论文
| 作者 | Xue, Kaizhong70,71; Gao, Bo68,69; Chen, Feng67; Wang, Meiyun65,66; Cheng, Jingliang64; Zhang, Bing63; Zhu, Wenzhen62; Qiu, Shijun61; Geng, Zuojun60; Zhang, Xiaochu59 |
| 刊名 | MOLECULAR PSYCHIATRY
 |
| 出版日期 | 2023-09-22 |
| 页码 | 14 |
| ISSN号 | 1359-4184 |
| DOI | 10.1038/s41380-023-02261-2 |
| 通讯作者 | Shen, Wen(shenwen66happy@163.com) ; Miao, Yanwei(ywmiao716@163.com) ; Yu, Chunshui(chunshuiyu@tmu.edu.cn) |
| 英文摘要 | Exposure to preadult environmental exposures may have long-lasting effects on mental health by affecting the maturation of the brain and personality, two traits that interact throughout the developmental process. However, environment-brain-personality covariation patterns and their mediation relationships remain unclear. In 4297 healthy participants (aged 18-30 years), we combined sparse multiple canonical correlation analysis with independent component analysis to identify the three-way covariation patterns of 59 preadult environmental exposures, 760 adult brain imaging phenotypes, and five personality traits, and found two robust environment-brain-personality covariation models with sex specificity. One model linked greater stress and less support to weaker functional connectivity and activity in the default mode network, stronger activity in subcortical nuclei, greater thickness and volume in the occipital, parietal and temporal cortices, and lower agreeableness, consciousness and extraversion as well as higher neuroticism. The other model linked higher urbanicity and better socioeconomic status to stronger functional connectivity and activity in the sensorimotor network, smaller volume and surface area and weaker functional connectivity and activity in the medial prefrontal cortex, lower white matter integrity, and higher openness to experience. We also conducted mediation analyses to explore the potential bidirectional mediation relationships between adult brain imaging phenotypes and personality traits with the influence of preadult environmental exposures and found both environment-brain-personality and environment-personality-brain pathways. We finally performed moderated mediation analyses to test the potential interactions between macro- and microenvironmental exposures and found that one category of exposure moderated the mediation pathways of another category of exposure. These results improve our understanding of the effects of preadult environmental exposures on the adult brain and personality traits and may facilitate the design of targeted interventions to improve mental health by reducing the impact of adverse environmental exposures. |
| 收录类别 | SCI |
| WOS关键词 | STRESS ; LIFE ; ADVERSITY ; MODEL ; RISK ; PATTERNS ; HEALTH ; ABUSE |
| 资助项目 | This work was funded by Natural Science Foundation of China (82030053), Tianjin Key Medical Discipline (Specialty) Construction Project (TJYXZDXK-001A) and Tsinghua-Toyota Joint Research Fund. No other disclosures were reported.[82030053] ; Natural Science Foundation of China[TJYXZDXK-001A] ; Tianjin Key Medical Discipline (Specialty) Construction Project ; Tsinghua-Toyota Joint Research Fund |
| WOS研究方向 | Biochemistry & Molecular Biology ; Neurosciences & Neurology ; Psychiatry |
| 语种 | 英语 |
| 出版者 | SPRINGERNATURE |
| WOS记录号 | WOS:001070335700001 |
| 资助机构 | This work was funded by Natural Science Foundation of China (82030053), Tianjin Key Medical Discipline (Specialty) Construction Project (TJYXZDXK-001A) and Tsinghua-Toyota Joint Research Fund. No other disclosures were reported. ; Natural Science Foundation of China ; Tianjin Key Medical Discipline (Specialty) Construction Project ; Tsinghua-Toyota Joint Research Fund |
| 源URL | [http://ir.psych.ac.cn/handle/311026/46125]  |
| 专题 | 心理研究所_认知与发展心理学研究室 |
| 通讯作者 | Shen, Wen; Miao, Yanwei; Yu, Chunshui |
| 作者单位 | 1.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai 200031, Peoples R China 2.Dalian Med Univ, Dept Radiol, Affiliated Hosp 1, Dalian 116011, Peoples R China 3.Tianjin First Ctr Hosp, Dept Radiol, Tianjin 300192, Peoples R China 4.Trinity Coll Dublin, Global Brain Hlth Inst, Dublin, Ireland 5.Trinity Coll Dublin, Sch Psychol, Dublin, Ireland 6.Charite Univ Med Berlin, Dept Psychiat & Neurosci, Ctr Populat Neurosci & Stratified Med PONS, Berlin, Germany 7.Tech Univ Dresden, Neuroimaging Ctr, Dresden, Germany 8.Tech Univ Dresden, Dept Psychiat, Dresden, Germany 9.Univ Med Ctr Hamburg Eppendorf, Dept Child & Adolescent Psychiat Psychotherapy &, Hamburg, Germany 10.Univ Med Ctr Gottingen, Dept Child & Adolescent Psychiat & Psychotherapy, Von Siebold Str 5, D-37075 Gottingen, Germany |
| 推荐引用方式 GB/T 7714 | Xue, Kaizhong,Gao, Bo,Chen, Feng,et al. Covariation of preadult environmental exposures, adult brain imaging phenotypes, and adult personality traits[J]. MOLECULAR PSYCHIATRY,2023:14. |
| APA | Xue, Kaizhong.,Gao, Bo.,Chen, Feng.,Wang, Meiyun.,Cheng, Jingliang.,...&Yu, Chunshui.(2023).Covariation of preadult environmental exposures, adult brain imaging phenotypes, and adult personality traits.MOLECULAR PSYCHIATRY,14. |
| MLA | Xue, Kaizhong,et al."Covariation of preadult environmental exposures, adult brain imaging phenotypes, and adult personality traits".MOLECULAR PSYCHIATRY (2023):14. |
入库方式： OAI收割
来源：心理研究所
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