基于分心与正念策略的虚拟现实场景的镇痛效果及其神经振荡机制
文献类型：学位论文
| 作者 | 李经纬
|
| 答辩日期 | 2023-06 |
| 文献子类 | 硕士 |
| 授予单位 | 中国科学院大学 |
| 授予地点 | 中国科学院心理研究所 |
| 其他责任者 | 吕雪靖 |
| 关键词 | 疼痛 虚拟现实 脑电图 镇痛 数字医疗 |
| 学位名称 | 理学硕士 |
| 学位专业 | 认知神经科学 |
| 其他题名 | The analgesic effects and neural oscillation mechanisms of virtual reality scenes based on distraction and mindfulness strategies |
| 中文摘要 | Since Virtual Reality (VR) has been used as a non-pharmaceutical adjunct to pain management, the analgesic effect of VR has been widely demonstrated in various pain conditions. However, there is no consensus on what kind of VR content is the best for pain alleviation and by what means VR modulates pain perception. To address these issues, the present study included three progressive experiments to explore the effect and neural mechanisms of VR-induced analgesia on contact heat pain by electroencephalogram (EEG). In a behavioral study (Experiment 1), fixed temperature stimuli (6/10 points for each participant) were delivered to the right forearm of 31 heap场subjects, and subjective pain intensity, unpleasantness, positive and negative emotions before and after interventions were compared in VR (multisensory information were presented), 2D (the same video as in VR was presented through a computer screen), and Control (no video was presented) intervention conditions. Results showed that the multisensory experience of VR effectively lowered the pain intensity and unpleasantness, maintained positive emotion, and reduced negative emotion. In an EEG study (Experiment 2) with the same design as in Experiment 1，data were collected from 24 healthy subjects. In addition to similar behavioral results as in Experiment 1，the reduction of contact heat stimuli evoked P2 responses were observed in the present experiment. Moreover, the reduced pain intensity rating was correlated with decreased P2 amplitude and increased spontaneous gamma oscillations, and the link between gamma oscillation and pain intensity was mediated by P2 amplitude, which suggested a possible neural pathway to explain the VR-induced analgesia. To explore the effects and neural mechanisms of analgesia induced by different VR scenes, an additional 24 subjects were recruited in Experiment 3.Results showed that VR scenes designed for distraction and mindfulness were associated with distinct neural mechanisms, but the analgesic effects were comparable. Specifically, distraction VR scene induced a sustained attention on multisensory information and enhanced spontaneous gamma oscillations, which further influenced pain processing; mindfulness VR scene was helpful to entered mindfulness state for subjects which was associated with the increase of alpha oscillation, produced an analgesic effect by affecting their own state. These results suggested that VR involved a top-down analgesic mechanism and different VR scenes were associated with different neural mechanisms. These results will help to understand the mechanisms of VR induced analgesia and develop more VR scenes for different pain conditions, facilitate the development of digital healthcare and help more patients to return to normal life. |
| 英文摘要 | 自虚拟现实技术(Virtual reality, VR)作为非药物镇痛的一种方式被应用于疼痛管理后，其镇痛效果已在多种疼痛环境中被证实。然而，关于VR调节疼痛的神经机制以及哪种VR场景可以产生更好的镇痛效果仍存在争议。为阐明VR镇痛的神经机制并探究不同VR场景镇痛效果的差异，本研究利用行为测量和脑电技术，通过三个循序渐进的实验探索VR对接触式热刺激的镇痛效果及相关神经机制。 实验一使用行为学方法，在31名健康被试右侧前臂施加固定强度的(被试主观疼痛评分为6/10分)脉冲式热刺激，比较被试在VR(使用VR), 2D(通过屏幕观看与VR内容相同的2D视频)、控制(无额外刺激)三种不同调控条件下的主观疼痛强度、疼痛不愉悦度以及测试前后积极情绪、消极情绪的变化验证VR的镇痛作用。结果表明，相较于控制条件和2D条件，使用VR可以显著降低个体的主观疼痛强度和和疼痛不愉悦度，并能维持积极情绪，减少消极情绪。 实验二采用与实验一相同的研究方法并同时记录脑电信号，共采集了24名健康被试的数据。结果显示，VR除了表现出与实验一相似的调控作用外，也降低了疼痛刺激诱发的P2响应的幅值，且P2幅值与主观疼痛强度有显著的正相关关系。此外，VR诱发的gamma频段的自发神经振荡也与主观疼痛强度有显著的相关关系，且gamma频段的神经振荡与疼痛强度的联系可由P2成分的幅值中介。此结果显示，gamma-P2一疼痛强度的中介效应是VR镇痛的一种可能的神经机制。 为探索分心、正念两种VR场景的镇痛效果及神经机制差异，实验三重新招募24名健康被试，采用与实验一、二相同的研究方法对比了被试在不同VR场景下的行为学及电生理差异。结果表明，分心与正念场景的镇痛效果没有差异，但两者涉及不同的神经机制。具体来说，分心场景可以使被试持续注意外界的视听刺激，诱发相关感觉脑区的gamma自发神经振荡活动增强，影响对疼痛信息的处理;正念场景则帮助被试进入正念状态，诱发的更强的alpha活动，通过影响自身状态产生镇痛效果。 这些结果表明VR涉及一种自上而下的镇痛机制，且基于不同策略的VR场景与不同的神经振荡机制有关。本研究结果有助于理解VR镇痛的神经机制，帮助开发更多适用于不同疼痛状况的VR场景，促进数字医疗的发展，帮助更多患者恢复正常生活。 |
| 语种 | 中文 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/46088]  |
| 专题 | 心理研究所_健康与遗传心理学研究室 |
| 推荐引用方式 GB/T 7714 | 李经纬. 基于分心与正念策略的虚拟现实场景的镇痛效果及其神经振荡机制[D]. 中国科学院心理研究所. 中国科学院大学. 2023. |
入库方式： OAI收割
来源：心理研究所
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