Alterations of interhemispheric functional homotopic connectivity and corpus callosum microstructure in bulimia nervosa
文献类型：期刊论文
| 作者 | Wang, Yiling4; Tang, Lirong3; Wang, Miao2; Li, Weihua4; Wang, Xuemei3; Wang, Jiani4; Yang, Zhenghan4; Chen, Qian4; Li, Xiaohong3; Li, Zhanjiang3 |
| 刊名 | QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
 |
| 出版日期 | 2023-09-19 |
| 页码 | 16 |
| ISSN号 | 2223-4292 |
| 关键词 | Bulimia nervosa (BN) interhemispheric communication corpus callosum (CC) voxel-mirrored homotopic connectivity (VMHC) functional connectivity (FC) |
| DOI | 10.21037/qims-23-18 |
| 通讯作者 | Wu, Guowei(wugw@psych.ac.cn) ; Zhang, Peng(zpqz1021@foxmail.com) ; Wang, Zhenchang(cjr.wzhch@vip.163.com) |
| 英文摘要 | Background: Accumulating evidences indicate maladaptive neural information interactions between different brain regions underlie bulimia nervosa (BN). However, little is known about the alterations in interhemispheric communication of BN, which is facilitated by the corpus callosum (CC), the major commissural fiber connecting the two hemispheres. To shed light on the interhemispheric communications in BN, the present study aims to explore alterations of interhemispheric homotopic functional connectivity and the CC microstructure in BN.Methods: Based on magnetic resonance imaging (MRI) data collected from 42 BN patients and 38 healthy controls (HCs), the group differences of voxel-mirrored homotopic connectivity (VMHC) index and CC white matter microstructure were compared. Then brain regions with significant group differences in VMHC were selected as seeds for subsequent functional connectivity (FC) analysis. Seed-based fiber tracking and correlation analysis were used to analyze the relationship between VMHC and CC changes. And correlation analysis was used to reveal the correlation between abnormal imaging variables and the clinical features of BN.Results: Compared with HCs, the BN group showed decreased fractional anisotropy (FA) in middle part of CC (CCMid) and increased VMHC in bilateral orbitofrontal cortex (OFC) and middle temporal gyrus (MTG) [false discovery rate (FDR) correction with a corrected threshold of P<0.05]. Subsequent FC analyses indicated increased FC between left OFC and right OFC, bilateral MTG, left middle occipital gyrus and right precuneus (PCUN); between right OFC and left cerebellum crus II and right PCUN; and between left MTG and right inferior temporal gyrus, right cerebellum lobule VI and right medial superior frontal gyrus (FDR correction with a corrected threshold of P<0.05). The VMHC values of OFC and MTG showed no correlations with FA values of the CCMid and the white fibers between the bilateral OFC and MTG were not through the CCMid. In addition, several regions with abnormal FC had a potential correlation trend with abnormal eating behaviors in BN patients (P<0.05, uncorrected).Conclusions: Aberrant interhemispheric homotopic functional connectivity and CC microstructure were observed in BN, and they may be independent of each other. Regions with aberrant interhemispheric homotopic functional connectivity showed hyperconnectivity with regions related to reward processing, body shape perception, and self-reference. |
| 收录类别 | SCI |
| WOS关键词 | BINGE-EATING DISORDER ; PSYCHOMETRIC PROPERTIES ; ANOREXIA-NERVOSA ; CHINESE VERSION ; DEFAULT-MODE ; REWARD ; POPULATION ; VALIDATION ; MOVEMENT ; IMAGES |
| 资助项目 | National Natural Science Foundation of China[82001790] ; Beijing Hospitals Authority Youth Programme[QML20191902] ; Beijing Friendship Hospital, Capital Medical University[YYZZ201917] ; Beijing Scholar 2015 ; Beijing key Clinical Discipline Funding[2021-135] ; Beijing Key Laboratory of Mental Disorders[2021JSJB03] |
| WOS研究方向 | Radiology, Nuclear Medicine & Medical Imaging |
| 语种 | 英语 |
| 出版者 | AME PUBLISHING COMPANY |
| WOS记录号 | WOS:001074118400001 |
| 资助机构 | National Natural Science Foundation of China ; Beijing Hospitals Authority Youth Programme ; Beijing Friendship Hospital, Capital Medical University ; Beijing Scholar 2015 ; Beijing key Clinical Discipline Funding ; Beijing Key Laboratory of Mental Disorders |
| 源URL | [http://ir.psych.ac.cn/handle/311026/46146]  |
| 专题 | 心理研究所_中国科学院行为科学重点实验室 |
| 通讯作者 | Wu, Guowei; Zhang, Peng; Wang, Zhenchang |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, 16 Lincui Rd, Beijing 100101, Peoples R China 2.Chinese Inst Brain Res, Beijing, Peoples R China 3.Capital Med Univ, Beijing Anding Hosp, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China 4.Capital Med Univ, Beijing Friendship Hosp, Dept Radiol, 95 Yongan Rd, Beijing 100050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yiling,Tang, Lirong,Wang, Miao,et al. Alterations of interhemispheric functional homotopic connectivity and corpus callosum microstructure in bulimia nervosa[J]. QUANTITATIVE IMAGING IN MEDICINE AND SURGERY,2023:16. |
| APA | Wang, Yiling.,Tang, Lirong.,Wang, Miao.,Li, Weihua.,Wang, Xuemei.,...&Wang, Zhenchang.(2023).Alterations of interhemispheric functional homotopic connectivity and corpus callosum microstructure in bulimia nervosa.QUANTITATIVE IMAGING IN MEDICINE AND SURGERY,16. |
| MLA | Wang, Yiling,et al."Alterations of interhemispheric functional homotopic connectivity and corpus callosum microstructure in bulimia nervosa".QUANTITATIVE IMAGING IN MEDICINE AND SURGERY (2023):16. |
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来源：心理研究所
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