Engineering Tridimensional Hydrogel Tissue and Organ Phantoms with Tunable Springiness
文献类型:期刊论文
作者 | Liu DS(刘德胜)4,5; Jiang P(蒋盼)4,5; Wang YX(汪祎贤)3; Lu YZ(鲁耀钟)5; Wu JY(吴家宇)2; Xu X(徐昕)2; Ji ZY(姬忠莹)1,5; Sun CF(孙初锋)3; Wang XL(王晓龙)1,4,5; Liu WM(刘维民)4,5 |
刊名 | Advanced Functional Materials |
出版日期 | 2023-01-31 |
卷号 | 33期号:17页码:202214885 |
关键词 | slippery vascular networks tissue-mimicking hydrogels tridimensional organ phantoms tunable springiness, vat photopolymerization 3D printing |
DOI | 10.1002/adfm.202214885 |
英文摘要 | Biomimicking organ phantoms with vivid biological structures and soft and slippery features are essential for in vitro biomedical applications yet remain hither to unmet challenges in their fabrication such as balancing between spatial structural complexity and matchable mechanical properties. Herein, 3D printable tissue-mimicking elastomeric double network hydrogels with tailorable stiffness are evolved to idiosyncratically match diverse biological soft tissues by regulating the compositions of hydrogel matrix and the density of metal coordination bonds. Relying on digital light processing 3D printing, various mechanically tunable biomimetic volumetric hydrogel organ constructs with structural complexity and fidelity, including kidney, brain, heart, liver, stomach, lung, trachea, intestine, and even the intricate vascularized tissues, are fabricated faultlessly. Proof-of-concept 3D printed hydrogel heart and liver phantoms provide sophisticated internal channels and cavity structures and external realistic anatomical architectures that more closely mimic native organs. For the in vitro application demonstration, a 3D printed hydrogel brain phantom with tortuous cerebral arteries and slippery characters serves as an effective neurosurgical training platform for realistic simulation of endovascular interventions. This platform offers a means to construct mechanically precisely tunable hydrogel-based biomimetic organ phantoms that are expected to be used in surgical training, medical device testing, and organs-on-chips. |
学科主题 | 材料科学 |
URL标识 | 查看原文 |
语种 | 英语 |
源URL | [http://ir.licp.cn/handle/362003/30182] |
专题 | 兰州化学物理研究所_固体润滑国家重点实验室 中国科学院兰州化学物理研究所 |
通讯作者 | Liu DS(刘德胜); Wang YX(汪祎贤); Liu WM(刘维民) |
作者单位 | 1.Shandong Laboratory of Yantai Advanced Materials and Green Manufacturing Yantai Zhongke Research Institute of Advanced Materials and Green Chemical Engineering Yantai 264006, China 2.School of Chemistry and Chemical Engineering Key Laboratory of Materials-Oriented Chemical Engineering of Xinjiang Uygur Autonomous Region Shihezi University Shihezi 832003, China 3.School of Chemical Engineering Northwest Minzu University Lanzhou 730030, China 4.Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China 5.State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Science, Lanzhou 730000, China |
推荐引用方式 GB/T 7714 | Liu DS,Jiang P,Wang YX,et al. Engineering Tridimensional Hydrogel Tissue and Organ Phantoms with Tunable Springiness[J]. Advanced Functional Materials,2023,33(17):202214885. |
APA | Liu DS.,Jiang P.,Wang YX.,Lu YZ.,Wu JY.,...&Liu WM.(2023).Engineering Tridimensional Hydrogel Tissue and Organ Phantoms with Tunable Springiness.Advanced Functional Materials,33(17),202214885. |
MLA | Liu DS,et al."Engineering Tridimensional Hydrogel Tissue and Organ Phantoms with Tunable Springiness".Advanced Functional Materials 33.17(2023):202214885. |
入库方式: OAI收割
来源:兰州化学物理研究所
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