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Chiral Recognition of D/L-Ribose by Visual and SERS Assessments

文献类型：期刊论文

作者Yao, Guohua1,2; Liu, Chao1; Elsherbiny, Shereen M.1; Huang, Qing1
刊名MOLECULES
出版日期2023-09-01
卷号28
关键词ribose chiral recognition visual sensor colorimetry SERS
DOI10.3390/molecules28186480
通讯作者Huang, Qing(huangq@ipp.ac.cn)
英文摘要Ribose is the central molecular unit in ribose nucleic acid (RNA). Ribose is a key molecule in the study of many persistent scientific mysteries, such as the origin of life and the chiral homogeneity of biological molecules. Therefore, the chiral recognition of ribose is of great significance. The traditional method of chiral recognition of ribose is HPLC, which is time-consuming, expensive, and can only be operated in the laboratory. There is no report on optical analytical techniques that can quickly detect the chirality of ribose. In this study, a simple and convenient approach for the chiral recognition of ribose has been developed. beta-cyclodextrin(beta-CD)-coated Ag NPs aggregate after adding D-ribose, so that D-/L-ribose can be identified using visual colorimetry and/or surface-enhanced Raman spectroscopy (SERS). The color change visible to the naked eye can readily distinguish the chirality of ribose, while the SERS method can provide the more sensitive analysis of enantiomeric ribose. The advantages of this method are that it is fast, convenient, low cost, and can be operated outside the laboratory. DFT calculations show that D-ribose and cyclodextrin have the same chirality, forming multiple strong hydrogen bonds between them; thus, D/L-ribose will induce different optical effects.
WOS关键词DENSITY FUNCTIONALS ; NONCOVALENT INTERACTIONS ; CRYSTAL-STRUCTURE ; ORIGIN ; PERFORMANCE ; ADSORPTION ; M06-2X ; SENSOR ; SUGARS ; DFT
资助项目National Natural Science Foundation of China[11635013] ; National Natural Science Foundation of China[21904127] ; National Key R&D Program of China[2022YFA1503504] ; Anhui Provincial Natural Science Foundation[1908085MB53]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
出版者MDPI
WOS记录号WOS:001077878700001
资助机构National Natural Science Foundation of China ; National Key R&D Program of China ; Anhui Provincial Natural Science Foundation
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/132504]  
专题中国科学院合肥物质科学研究院
通讯作者Huang, Qing
作者单位1.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Intelligent Machines, CAS Key Lab Ion Beam Bioengn, Hefei 230031, Peoples R China
2.Shanghai Normal Univ, Joint Int Res Lab Resource Chem, Educ Minist Key Lab Resource Chem, Minist Educ,Shanghai Noncarbon Energy Convers & Ut, Shanghai 200234, Peoples R China
推荐引用方式
GB/T 7714		 Yao, Guohua,Liu, Chao,Elsherbiny, Shereen M.,et al. Chiral Recognition of D/L-Ribose by Visual and SERS Assessments[J]. MOLECULES,2023,28.
APA Yao, Guohua,Liu, Chao,Elsherbiny, Shereen M.,&Huang, Qing.(2023).Chiral Recognition of D/L-Ribose by Visual and SERS Assessments.MOLECULES,28.
MLA Yao, Guohua,et al."Chiral Recognition of D/L-Ribose by Visual and SERS Assessments".MOLECULES 28(2023).

入库方式： OAI收割

来源：合肥物质科学研究院

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