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Programmable DNA hydrogel provides suitable microenvironment for enhancing autophagy-based therapies in intervertebral disc degeneration treatment

文献类型：期刊论文

作者Qingxin, Song5; Kai, Jiang4; Dandan, Zheng5; Linyu, Jin3; Xiuyuan, Chen5; Yubo, Feng5; Kun, Wang5; Yingchao, Han5; Hao, Chen5; Jie, Song1,2
刊名JOURNAL OF NANOBIOTECHNOLOGY
出版日期2023-09-28
卷号21
关键词Intervertebral disc degeneration Gene therapy DNA hydrogel Autophagy Extracellular matrix
DOI10.1186/s12951-023-02109-5
通讯作者Jie, Song(sjie@sjtu.edu.cn) ; Zhi, Chen(mcgrady923@126.com) ; Hongxing, Shen(shenhxgk@126.com)
英文摘要The pathogenesis of intervertebral disc degeneration (IVDD) is attributed to metabolic dysregulation within the extracellular matrix and heightened apoptosis of nucleus pulposus cells (NPC). Therefore, a potential therapeutic strategy for managing IVDD involves the reestablishment of metabolic equilibrium within the extracellular matrix and the suppression of excessive myeloid cell apoptosis. The microRNA, miR-5590, displays marked differential expression in degenerative nucleus pulposus (NP) tissues and exerts a direct influence on the regulation of DDX5 expression. This, in turn, modulates mammalian target of rapamycin (mTOR) phosphorylation, thereby impacting autophagy and apoptosis. However, ensuring the smooth delivery of miRNA to a specific injury site poses a significant challenge. To address this issue, a multifunctional DNA hydrogel was developed and subsequently loaded with miR-5590 via spherical nucleic acids (SNAs) for the treatment of IVDD. The hydrogel, which exhibits versatility, has the potential to be administered through injection at the site of injury, resulting in a consistent and prolonged release of miR-5590. This leads to the creation of a genetic microenvironment within the NP, which triggers the onset of autophagy in NPCs and subsequently suppresses apoptosis. As a result, this process regulates the metabolic equilibrium within the extracellular matrix, thereby impeding the in vitro and in vivo progression of IVDD. The amalgamation of miRNAs and biomaterials offers a promising therapeutic strategy for the management of IVDD in clinical settings.
WOS关键词NUCLEUS PULPOSUS ; SENESCENCE
资助项目We thank the Instrumental Analysis Center of Shanghai Jiao Tong University for materials testing.
WOS研究方向Biotechnology & Applied Microbiology ; Science & Technology - Other Topics
语种英语
出版者BMC
WOS记录号WOS:001074913900001
资助机构We thank the Instrumental Analysis Center of Shanghai Jiao Tong University for materials testing.
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/132579]  
专题中国科学院合肥物质科学研究院
通讯作者Jie, Song; Zhi, Chen; Hongxing, Shen
作者单位1.Univ Chinese Acad Sci, Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China
2.Shanghai Jiao Tong Univ, Sch Elect Informat & Elect Engn, Dept Instrument Sci & Engn, Shanghai 200240, Peoples R China
3.Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Inst Traumatol & Orthoped, Dept Orthoped,Shanghai Key Lab Prevent & Treatment, Shanghai, Peoples R China
4.Fudan Univ, Ear Nose & Throat Hosp, Dept Ophthalmol & Vis Sci, Shanghai Eye, Shanghai, Peoples R China
5.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Spine Surg, 160 Pujian Rd, Shanghai 200127, Peoples R China
推荐引用方式
GB/T 7714		 Qingxin, Song,Kai, Jiang,Dandan, Zheng,et al. Programmable DNA hydrogel provides suitable microenvironment for enhancing autophagy-based therapies in intervertebral disc degeneration treatment[J]. JOURNAL OF NANOBIOTECHNOLOGY,2023,21.
APA Qingxin, Song.,Kai, Jiang.,Dandan, Zheng.,Linyu, Jin.,Xiuyuan, Chen.,...&Hongxing, Shen.(2023).Programmable DNA hydrogel provides suitable microenvironment for enhancing autophagy-based therapies in intervertebral disc degeneration treatment.JOURNAL OF NANOBIOTECHNOLOGY,21.
MLA Qingxin, Song,et al."Programmable DNA hydrogel provides suitable microenvironment for enhancing autophagy-based therapies in intervertebral disc degeneration treatment".JOURNAL OF NANOBIOTECHNOLOGY 21(2023).

入库方式： OAI收割

来源：合肥物质科学研究院

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