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Aberrant degree centrality profiles during rumination in major depressive disorder

文献类型：期刊论文

作者Jia, Feng-Nan13,14; Chen, Xiao8,9,10,11,12; Du, Xiang-Dong13; Tang, Zhen13; Ma, Xiao-Yun13; Ning, Tian-Tian13; Zou, Si-Yun13; Zuo, Shang-Fu7; Li, Hui-Xian6; Cui, Shi-Xian4,5,9,10,12
刊名HUMAN BRAIN MAPPING
出版日期2023-10-14
页码13
ISSN号1065-9471
关键词degree centrality dorsal attention network executive function fMRI major depressive disorder rumination
DOI10.1002/hbm.26510
通讯作者Liu, Yan-Song(lysway@163.com)
英文摘要Rumination is closely linked to the onset and maintenance of major depressive disorder (MDD). Prior neuroimaging studies have identified the association between self-reported rumination trait and the functional coupling among a network of brain regions using resting-state functional magnetic resonance imaging (MRI). However, little is known about the underlying neural circuitry mechanism during active rumination in MDD. Degree centrality (DC) is a simple metric to denote network integration, which is critical for higher-order psychological processes such as rumination. During an MRI scan, individuals with MDD (N = 45) and healthy controls (HC, N = 46) completed a rumination state task. We examined the interaction effect between the group (MDD vs. HC) and condition (rumination vs. distraction) on vertex-wise DC. We further characterized the identified brain region's functional involvement with Neurosynth and BrainMap. Network-wise seed-based functional connectivity (FC) analysis was also conducted for the identified region of interest. Finally, exploratory correlation analysis was conducted between the identified region of interest's network FCs and self-reported in-scanner affect levels. We found that a left superior frontal gyrus (SFG) region, generally overlapped with the frontal eye field, showed a significant interaction effect. Further analysis revealed its involvement with executive functions. FCs between this region, the frontoparietal, and the dorsal attention network (DAN) also showed significant interaction effects. Furthermore, its FC to DAN during distraction showed a marginally significant negative association with in-scanner affect level at the baseline. Our results implicated an essential role of the left SFG in the rumination's underlying neural circuitry mechanism in MDD and provided novel evidence for the conceptualization of rumination in terms of impaired executive control.
收录类别SCI
WOS关键词FUNCTIONAL CONNECTIVITY ; EXECUTIVE FUNCTIONS ; COGNITIVE CONTROL ; NETWORK CONNECTIVITY ; RESIDUAL DEPRESSION ; NEGATIVE THINKING ; HUMAN BRAIN ; CORTEX ; DISENGAGEMENT ; THERAPY
资助项目This work was funded by the Sci-Tech Innovation 2030-Major Project of Brain-inspired Intelligence Technology No. 2021ZD0200600; National Key Ramp;D Program of China No. 2017YFC1309902; the National Natural Science Foundation of China Nos. 82122035, 816717[2021ZD0200600] ; Sci-Tech Innovation[2017YFC1309902] ; National Key Ramp;D Program of China[82122035] ; National Key Ramp;D Program of China[81671774] ; National Key Ramp;D Program of China[81630031] ; National Natural Science Foundation of China[XXH13505] ; 13th Five-year Informatization Plan of Chinese Academy of Sciences[ZDBS-SSW-JSC006] ; Key Research Program of the Chinese Academy of Sciences[Z191100001119104] ; Beijing Nova Program of Science and Technology[E2CX4425YZ] ; Beijing Nova Program of Science and Technology[Y9CX422005] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[2019M660847] ; China Postdoctoral Science Foundation[BX20200360] ; China National Postdoctoral Program for Innovative Talents[E2CX0624] ; Special Research Assistant Program of the Chinese Academy of Sciences[GSWS2021053] ; Suzhou Gusu Health Talents Scientific Research Project[Szlcyxzx202109] ; Suzhou Clinical Medical Center for Mood Disorders ; Program of the Jiangsu Commission of Health[BK20201177] ; Natural Science Foundation of Jiangsu Province[SLT2021014] ; Suzhou Municipal Bureau of Science and Technology Clinical Trial Institution Capacity Improvement Project[ZKS1940] ; Zhangjiagang Science and Technology Support Plan Project[SYS2020194] ; Zhangjiagang Science and Technology Support Plan Project[KJXW2020052] ; Suzhou Science and Technology Project[202104910248] ; China Scholarship Council (CSC) ; Centre for Addiction and Mental Health
WOS研究方向Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
语种英语
出版者WILEY
WOS记录号WOS:001084386300001
资助机构This work was funded by the Sci-Tech Innovation 2030-Major Project of Brain-inspired Intelligence Technology No. 2021ZD0200600; National Key Ramp;D Program of China No. 2017YFC1309902; the National Natural Science Foundation of China Nos. 82122035, 816717 ; Sci-Tech Innovation ; National Key Ramp;D Program of China ; National Natural Science Foundation of China ; 13th Five-year Informatization Plan of Chinese Academy of Sciences ; Key Research Program of the Chinese Academy of Sciences ; Beijing Nova Program of Science and Technology ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; China National Postdoctoral Program for Innovative Talents ; Special Research Assistant Program of the Chinese Academy of Sciences ; Suzhou Gusu Health Talents Scientific Research Project ; Suzhou Clinical Medical Center for Mood Disorders ; Program of the Jiangsu Commission of Health ; Natural Science Foundation of Jiangsu Province ; Suzhou Municipal Bureau of Science and Technology Clinical Trial Institution Capacity Improvement Project ; Zhangjiagang Science and Technology Support Plan Project ; Suzhou Science and Technology Project ; China Scholarship Council (CSC) ; Centre for Addiction and Mental Health
源URL[http://ir.psych.ac.cn/handle/311026/46252]  
专题心理研究所_中国科学院行为科学重点实验室
通讯作者Liu, Yan-Song
作者单位1.Soochow Univ, Affiliated Guangji Hosp, 11 Guangqian Rd, Suzhou 215137, Jiangsu, Peoples R China
2.Soochow Univ, Suzhou Psychiat Hosp, Dept Radiol, Dept Psychiat,Affiliated Guangji Hosp, Suzhou, Jiangsu, Peoples R China
3.Zhangjiagang Fourth Peoples Hosp, Dept Psychol, Zhangjiagang, Jiangsu, Peoples R China
4.Sino Danish Ctr Educ & Res, Beijing, Peoples R China
5.Univ Chinese Acad Sci, Sino Danish Coll, Beijing, Peoples R China
6.Zhengzhou Univ, Dept Obstet & Gynecol, Affiliated Hosp 3, Zhengzhou, Henan, Peoples R China
7.Boston Univ, Chobanian & Avedisian Sch Med, Boston, MA USA
8.Chinese Acad Sci, Int Big Data Ctr Depress Res, Beijing, Peoples R China
9.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing, Peoples R China
10.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Jia, Feng-Nan,Chen, Xiao,Du, Xiang-Dong,et al. Aberrant degree centrality profiles during rumination in major depressive disorder[J]. HUMAN BRAIN MAPPING,2023:13.
APA Jia, Feng-Nan.,Chen, Xiao.,Du, Xiang-Dong.,Tang, Zhen.,Ma, Xiao-Yun.,...&Liu, Yan-Song.(2023).Aberrant degree centrality profiles during rumination in major depressive disorder.HUMAN BRAIN MAPPING,13.
MLA Jia, Feng-Nan,et al."Aberrant degree centrality profiles during rumination in major depressive disorder".HUMAN BRAIN MAPPING (2023):13.

入库方式： OAI收割

来源：心理研究所

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