Solvent effects on the crystallization of avermectin B1a
文献类型：期刊论文
| 作者 | Liu, Ji; Chang, Zhidong; He, Yi; Yang, Mingde; Dang, Jie |
| 刊名 | JOURNAL OF CRYSTAL GROWTH
 |
| 出版日期 | 2007-09-01 |
| 卷号 | 307期号:1页码:131-136 |
| 关键词 | avermectin b1a crystallization crystal morphology impurity nucleation solvent effects |
| ISSN号 | 0022-0248 |
| 其他题名 | J. Cryst. Growth |
| 中文摘要 | Effects of different solvents including methanol, ethanol, and n-butylalcohol on the crystallization of avermectin B1a were studied in this paper. In pure crystallization system, solvent effects on nucleation rate and crystal morphology were studied by varying relative supersaturation ratio, which was 1.3-2.8 for methanol, 1.8-2.8 for ethanol, and 2.8-4.5 for n-butylalcohol respectively. Results showed that the nucleation rate of avermectin B1a decreased in the order of crystallization solvents methanol, ethanol, and n-butylalcohol, and the crystal morphology transited from needle like to distorted cube shape. Purification effect of the crystallization process was studied through the segregation coefficient of B2a. The study was carried out by varying the supersaturation ratio as well as the amount of impurity (B2a, 8.7-26.1%, w/w). The segregation coefficient study indicated that the purification effect of the crystallization decreased with increasing supersaturation and purity of the crystallization system. In addition, crystallization with methanol and n-butylalcohol could remove impurities better than with ethanol. (C) 2007 Elsevier B.V. All rights reserved. |
| 英文摘要 | Effects of different solvents including methanol, ethanol, and n-butylalcohol on the crystallization of avermectin B1a were studied in this paper. In pure crystallization system, solvent effects on nucleation rate and crystal morphology were studied by varying relative supersaturation ratio, which was 1.3-2.8 for methanol, 1.8-2.8 for ethanol, and 2.8-4.5 for n-butylalcohol respectively. Results showed that the nucleation rate of avermectin B1a decreased in the order of crystallization solvents methanol, ethanol, and n-butylalcohol, and the crystal morphology transited from needle like to distorted cube shape. Purification effect of the crystallization process was studied through the segregation coefficient of B2a. The study was carried out by varying the supersaturation ratio as well as the amount of impurity (B2a, 8.7-26.1%, w/w). The segregation coefficient study indicated that the purification effect of the crystallization decreased with increasing supersaturation and purity of the crystallization system. In addition, crystallization with methanol and n-butylalcohol could remove impurities better than with ethanol. (C) 2007 Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Physical Sciences ; Technology |
| 类目[WOS] | Crystallography ; Materials Science, Multidisciplinary ; Physics, Applied |
| 研究领域[WOS] | Crystallography ; Materials Science ; Physics |
| 关键词[WOS] | SUCCINIC ACID CRYSTALS ; MORPHOLOGY ; GROWTH ; IMPURITY |
| 收录类别 | SCI |
| 原文出处 | |
| 语种 | 英语 |
| WOS记录号 | WOS:000249801600023 |
| 公开日期 | 2013-10-15 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/3390]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | 1.Tsing Hua Univ, Inst Nucl & New Energy Technol, Beijing 100084, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Ji,Chang, Zhidong,He, Yi,et al. Solvent effects on the crystallization of avermectin B1a[J]. JOURNAL OF CRYSTAL GROWTH,2007,307(1):131-136. |
| APA | Liu, Ji,Chang, Zhidong,He, Yi,Yang, Mingde,&Dang, Jie.(2007).Solvent effects on the crystallization of avermectin B1a.JOURNAL OF CRYSTAL GROWTH,307(1),131-136. |
| MLA | Liu, Ji,et al."Solvent effects on the crystallization of avermectin B1a".JOURNAL OF CRYSTAL GROWTH 307.1(2007):131-136. |
入库方式： OAI收割
来源：过程工程研究所
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