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Cofactor regeneration for sustainable enzymatic biosynthesis
文献类型：期刊论文
| 作者 | Liu, Wenfang; Wang, Ping |
| 刊名 | BIOTECHNOLOGY ADVANCES
 |
| 出版日期 | 2007-07-01 |
| 卷号 | 25期号:4页码:369-384 |
| 关键词 | oxidoreductases enzyme immobilization cofactor regeneration biocatalysis biosynthesis industrial biotechnology |
| ISSN号 | 0734-9750 |
| 其他题名 | Biotechnol. Adv. |
| 中文摘要 | Oxidoreductases are attractive catalysts for biosynthesis of chiral compounds and polymers, construction of biosensors, and degradation of environmental pollutants. Their practical applications, however, can be quite challenging since they often require cofactors such as nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). These cofactors are generally expensive. Efficient regeneration of cofactors is therefore critical to the economic viability of industrial-scale biotransformations using oxidoreductases. The chemistry of cofactor regeneration is well known nowadays. The challenge is mostly regarding how to achieve the regeneration with immobilized enzyme systems which are preferred for industrial processes to facilitate the recovery and continuous use of the catalysts. This has become a great hurdle for the industrialization of many promising enzymatic processes, and as a result, most of the biotransformations involving cofactors have been traditionally performed with living cells in industry. Accompanying the rapidly growing interest in industrial biotechnology, immobilized enzyme biocatalyst systems with cofactor regeneration have been the focus for many studies reported since the late 1990s. The current paper reviews the methods of cofactor retention for development of sustainable and regenerative biocatalysts as revealed in these recent studies, with the intent to complement other reviewing articles that are mostly regeneration chemistry-oriented. We classify in this paper the methods of sustainable cofactor regeneration into two categories, namely membrane entrapment and solid-attachment of cofactors. (c) 2007 Elsevier Inc. All rights reserved. |
| 英文摘要 | Oxidoreductases are attractive catalysts for biosynthesis of chiral compounds and polymers, construction of biosensors, and degradation of environmental pollutants. Their practical applications, however, can be quite challenging since they often require cofactors such as nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). These cofactors are generally expensive. Efficient regeneration of cofactors is therefore critical to the economic viability of industrial-scale biotransformations using oxidoreductases. The chemistry of cofactor regeneration is well known nowadays. The challenge is mostly regarding how to achieve the regeneration with immobilized enzyme systems which are preferred for industrial processes to facilitate the recovery and continuous use of the catalysts. This has become a great hurdle for the industrialization of many promising enzymatic processes, and as a result, most of the biotransformations involving cofactors have been traditionally performed with living cells in industry. Accompanying the rapidly growing interest in industrial biotechnology, immobilized enzyme biocatalyst systems with cofactor regeneration have been the focus for many studies reported since the late 1990s. The current paper reviews the methods of cofactor retention for development of sustainable and regenerative biocatalysts as revealed in these recent studies, with the intent to complement other reviewing articles that are mostly regeneration chemistry-oriented. We classify in this paper the methods of sustainable cofactor regeneration into two categories, namely membrane entrapment and solid-attachment of cofactors. (c) 2007 Elsevier Inc. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biotechnology & Applied Microbiology |
| 研究领域[WOS] | Biotechnology & Applied Microbiology |
| 关键词[WOS] | LIVER ALCOHOL-DEHYDROGENASE ; NICOTINAMIDE ADENINE-DINUCLEOTIDE ; IMMOBILIZED MULTIENZYME SYSTEM ; CHARGED MEMBRANE BIOREACTOR ; PRINTED CARBON ELECTRODE ; ESSENTIAL AMINO-ACIDS ; SOLID BINDING MATRIX ; ARTIFICIAL CELLS ; AMPEROMETRIC BIOSENSORS ; GLUCOSE-DEHYDROGENASE |
| 收录类别 | SCI |
| 原文出处 | |
| 语种 | 英语 |
| WOS记录号 | WOS:000247664200003 |
| 公开日期 | 2013-10-15 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/3394]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | 1.Univ Minnesota, Dept Bioprod & Biosyst Engn, St Paul, MN 55108 USA 2.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Wenfang,Wang, Ping. Cofactor regeneration for sustainable enzymatic biosynthesis[J]. BIOTECHNOLOGY ADVANCES,2007,25(4):369-384. |
| APA | Liu, Wenfang,&Wang, Ping.(2007).Cofactor regeneration for sustainable enzymatic biosynthesis.BIOTECHNOLOGY ADVANCES,25(4),369-384. |
| MLA | Liu, Wenfang,et al."Cofactor regeneration for sustainable enzymatic biosynthesis".BIOTECHNOLOGY ADVANCES 25.4(2007):369-384. |
入库方式： OAI收割
来源：过程工程研究所
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