Engineering Single-Atom Iron Nanozymes with Radiation-Enhanced Self-Cascade Catalysis and Self-Supplied H2O2 for Radio- enzymatic Therapy
文献类型：期刊论文
| 作者 | Zhu, XY; Wu, JB ; Liu, RX; Xiang, HD; Zhang, WQ; Chang, QC; Wang, SS; Jiang, R; Zhao, F; Li, QQ
|
| 刊名 | ACS NANO
 |
| 出版日期 | 2022 |
| 卷号 | 16期号:11页码:18849-18862 |
| ISSN号 | 1936-0851 |
| 关键词 | single-atom iron nanozyme external-?eld-enhanced catalysis enzymatic therapy radiotherapy |
| DOI | 10.1021/acsnano.2c07691 |
| 文献子类 | Article |
| 英文摘要 | Single-atom nanozymes (SAzymes), with individually isolated metal atom as active sites, have shown tremendous potential as enzyme-based drugs for enzymatic therapy. However, using SAzymes in tumor theranostics remains challenging because of deficient enzymatic activity and insufficient endogenous H2O2. We develop an external-field-enhanced catalysis by an atom-level engineered FeN4-centered nanozyme (FeN4-SAzyme) for radio-enzymatic therapy. This FeN4-SAzyme exhibits peroxidase-like activity capable of catalyzing H2O2 into hydroxyl radicals and converting single-site FeII species to FeIII for subsequent glutathione oxidase-like activity. Density functional theory calcu-lations are used to rationalize the origin of the single-site self-cascade enzymatic activity. Importantly, using X-rays can improve the overall single-site cascade enzymatic reaction process via promoting the conversion frequency of FeII/FeIII. As a H2O2 producer, natural glucose oxidase is further decorated onto the surface of FeN4-SAzyme to yield the final construct GOD@FeN4-SAzyme. The resulting GOD@FeN4-SAzyme not only supplies in situ H2O2 to continuously produce highly toxic hydroxyl radicals but also induces the localized deposition of radiation dose, subsequently inducing intensive apoptosis and ferroptosis in vitro. Such a synergistic effect of radiotherapy and self-cascade enzymatic therapy allows for improved tumor growth inhibition with minimal side effects in vivo. Collectively, this work demonstrates the introduction of external fields to enhance enzyme-like performance of nanozymes without changing their properties and highlights a robust therapeutic capable of self-supplying H2O2 and amplifying self-cascade reactions to address the limitations of enzymatic treatment. |
| 电子版国际标准刊号 | 1936-086X |
| 语种 | 英语 |
| WOS记录号 | WOS:000877342100001 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/299092]  |
| 专题 | 高能物理研究所_多学科研究中心 高能物理研究所_实验物理中心 高能物理研究所_理论物理室 高能物理研究所_东莞分部 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Zhu, XY,Wu, JB,Liu, RX,et al. Engineering Single-Atom Iron Nanozymes with Radiation-Enhanced Self-Cascade Catalysis and Self-Supplied H2O2 for Radio- enzymatic Therapy[J]. ACS NANO,2022,16(11):18849-18862. |
| APA | Zhu, XY.,Wu, JB.,Liu, RX.,Xiang, HD.,Zhang, WQ.,...&Zhao, YL.(2022).Engineering Single-Atom Iron Nanozymes with Radiation-Enhanced Self-Cascade Catalysis and Self-Supplied H2O2 for Radio- enzymatic Therapy.ACS NANO,16(11),18849-18862. |
| MLA | Zhu, XY,et al."Engineering Single-Atom Iron Nanozymes with Radiation-Enhanced Self-Cascade Catalysis and Self-Supplied H2O2 for Radio- enzymatic Therapy".ACS NANO 16.11(2022):18849-18862. |
入库方式： OAI收割
来源：高能物理研究所
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