Tailored Cross-beta Assemblies Establish Peptide Dominos Structures for Anchoring Undruggable Pharmacophores
文献类型：期刊论文
| 作者 | Zhang, LM; Li, MZ ; Wang, MX; Li, LY; Guo, MM; Ke, YB; Zhou, P; Wang, WZ
|
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2022 |
| 卷号 | 61期号:51页码:e202212527 |
| ISSN号 | 1433-7851 |
| 关键词 | Dominos PD-L1 Peptides Self-Assembly beta-Sheets |
| DOI | 10.1002/anie.202212527 |
| 文献子类 | Article |
| 英文摘要 | beta-sheets have the ability to hierarchically stack into assemblies, and much effort has been spent on designing different peptides to regulate their assembly behaviors. Although the progress is remarkable, it remains challenging to manipulate them in a controllable way for achieving both tailored structures and specific functions. In this study, we obtained bola-like peptides using de novo design and combinatorial chemical screening. By regulating the solvent-accessible surface area of the peptide chain, a series of assemblies with different tilt angles and active sites of the beta-sheet were obtained, resembling collapsed dominos. The structure-activity relationship of the optimized peptide NQ40 system was established and its ability to target the PD-Ll was demonstrated. This study successfully established the structure-function relationship of beta-sheets assemblies and has positive implications on the rational design of peptide assemblies that possess recognition abilities. |
| 电子版国际标准刊号 | 1521-3773 |
| 语种 | 英语 |
| WOS记录号 | WOS:000888950800001 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/299181]  |
| 专题 | 高能物理研究所_实验物理中心 高能物理研究所_东莞分部 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, LM,Li, MZ,Wang, MX,et al. Tailored Cross-beta Assemblies Establish Peptide Dominos Structures for Anchoring Undruggable Pharmacophores[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2022,61(51):e202212527. |
| APA | Zhang, LM.,Li, MZ.,Wang, MX.,Li, LY.,Guo, MM.,...&Wang, WZ.(2022).Tailored Cross-beta Assemblies Establish Peptide Dominos Structures for Anchoring Undruggable Pharmacophores.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,61(51),e202212527. |
| MLA | Zhang, LM,et al."Tailored Cross-beta Assemblies Establish Peptide Dominos Structures for Anchoring Undruggable Pharmacophores".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 61.51(2022):e202212527. |
入库方式： OAI收割
来源：高能物理研究所
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