Tuning iron spin states in single-atom nanozymes enables efficient peroxidase mimicking
文献类型：期刊论文
| 作者 | Wei, XQ; Song, SJ; Song, WY ; Wen, YT; Xu, WQ; Chen, YF; Wu, ZC; Qin, Y; Jiao, L; Wu, Y
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| 刊名 | CHEMICAL SCIENCE
 |
| 出版日期 | 2022 |
| 卷号 | 13期号:45页码:13574-13851 |
| ISSN号 | 2041-6520 |
| DOI | 10.1039/d2sc05679h |
| 文献子类 | Article |
| 英文摘要 | The large-scale application of nanozymes remains a significant challenge owing to their unsatisfactory catalytic performances. Featuring a unique electronic structure and coordination environment, single-atom nanozymes provide great opportunities to vividly mimic the specific metal catalytic center of natural enzymes and achieve superior enzyme-like activity. In this study, the spin state engineering of Fe single-atom nanozymes (FeNC) is employed to enhance their peroxidase-like activity. Pd nanoclusters (Pd-NC) are introduced into FeNC, whose electron-withdrawing properties rearrange the spin electron occupation in Fe(ii) of FeNC-Pd-NC from low spin to medium spin, facilitating the heterolysis of H2O2 and timely desorption of H2O. The spin-rearranged FeNC-Pd-NC exhibits greater H2O2 activation activity and rapid reaction kinetics compared to those of FeNC. As a proof of concept, FeNC-Pd-NC is used in the immunosorbent assay for the colorimetric detection of prostate-specific antigen and achieves an ultralow detection limit of 0.38 pg mL(-1). Our spin-state engineering strategy provides a fundamental understanding of the catalytic mechanism of nanozymes and facilitates the design of advanced enzyme mimics. |
| 电子版国际标准刊号 | 2041-6539 |
| 语种 | 英语 |
| WOS记录号 | WOS:000884104400001 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/299343]  |
| 专题 | 高能物理研究所_实验物理中心 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Wei, XQ,Song, SJ,Song, WY,et al. Tuning iron spin states in single-atom nanozymes enables efficient peroxidase mimicking[J]. CHEMICAL SCIENCE,2022,13(45):13574-13851. |
| APA | Wei, XQ.,Song, SJ.,Song, WY.,Wen, YT.,Xu, WQ.,...&Zhu, CZ.(2022).Tuning iron spin states in single-atom nanozymes enables efficient peroxidase mimicking.CHEMICAL SCIENCE,13(45),13574-13851. |
| MLA | Wei, XQ,et al."Tuning iron spin states in single-atom nanozymes enables efficient peroxidase mimicking".CHEMICAL SCIENCE 13.45(2022):13574-13851. |
入库方式： OAI收割
来源：高能物理研究所
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