Probing paeonol-pluronic polymer interactions by H-1 NMR spectroscopy
文献类型：期刊论文
| 作者 | Ma, J. H. ; Guo, C. ; Tang, Y. L. ; Zhang, H. ; Liu, H. Z. |
| 刊名 | Journal of Physical Chemistry B
 |
| 出版日期 | 2007 |
| 期号 | 47页码:13371-13378 |
| 关键词 | block-copolymer micelles magnetic-resonance-spectroscopy oxide) triblock copolymer ordered 2d nmr drug-delivery aqueous-solutions nonionic surfactants binding-affinity release micellization |
| 其他题名 | J. Phys. Chem. B |
| 中文摘要 | By using a combination of H-1 NMR spectroscopy, two-dimensional heteronuclear single-quantum coherence-resolved H-1{C-13} and homonuclear rotating-frame Overhauser enhancement NMR correlation experiments with diffusion ordered spectroscopy (DOSY), the location and distribution of a hydrophobic drug, paeonol, have been established with respect to the methyl groups of the poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) triblock copolymer. The interaction between them is adjustable according to the different temperature-dependent hydrophilicities or hydrophobicities of the triblock copolymer components. On the other hand, such interactions influence the self-assembly properties of the block copolymer amphiphiles in solution. The amount of anhydrous methyl groups of PPO segments shows an increase with increasing paeonol concentration. It was also demonstrated that the shell-crosslinking of the Pluronic polymer has an effect in increasing the amount of anhydrous methyl groups and thus increasing the hydrophobicity of Pluronic micelles. This might be the deeper reason underlying the increase in drug-loading capacity and prolongation in release time of Pluronic micelles for drug delivery after the shell-crosslinking. Changes in self-diffusion coefficients of paeonol with varying copolymer concentrations and types were also determined by the diffusion-based NMR DOSY technique, and values of K-a, Delta G, and n were calculated. |
| 原文出处 | |
| 语种 | 英语 |
| 公开日期 | 2013-10-15 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/3410]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 推荐引用方式 GB/T 7714 | Ma, J. H.,Guo, C.,Tang, Y. L.,et al. Probing paeonol-pluronic polymer interactions by H-1 NMR spectroscopy[J]. Journal of Physical Chemistry B,2007(47):13371-13378. |
| APA | Ma, J. H.,Guo, C.,Tang, Y. L.,Zhang, H.,&Liu, H. Z..(2007).Probing paeonol-pluronic polymer interactions by H-1 NMR spectroscopy.Journal of Physical Chemistry B(47),13371-13378. |
| MLA | Ma, J. H.,et al."Probing paeonol-pluronic polymer interactions by H-1 NMR spectroscopy".Journal of Physical Chemistry B .47(2007):13371-13378. |
入库方式： OAI收割
来源：过程工程研究所
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