In Situ Formed Z-Scheme Graphdiyne Heterojunction Realizes NIR-Photocatalytic Oxygen Evolution and Selective Radiosensitization for Hypoxic Tumors
文献类型：期刊论文
| 作者 | Wang, Dongmei,; Liao, You,; Yan, Haili; Zhu, Shuang,; Liu, Yunpeng ; Li, Jian; Wang, Xue,; Guo, Xihong; Gu, Zhanjun,; Sun, Baoyun,
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| 刊名 | ACS Nano
 |
| 出版日期 | 2022 |
| 卷号 | 16期号:12页码:21186-21198 |
| ISSN号 | 19360851 |
| DOI | 10.1021/acsnano.2c09169 |
| 文献子类 | Article |
| 英文摘要 | Photon radiotherapy is a common tool in the armory against tumors, but it is limited by hypoxia-related radioresistance of tumors and radiotoxicity to normal tissues. Here, we constructed a spatiotemporally controlled synergistic therapy platform based on the heterostructured CuO@Graphdiyne (CuO@GDY) nanocatalyst for simultaneously addressing the two key problems above in radiotherapy. First, the in situ formed Z-scheme CuO@GDY heterojunction performs highly efficient and controlled photocatalytic O2evolution upon near-infrared (NIR) laser stimulation for tumor hypoxia alleviation. Subsequently, the CuO@GDY nanocatalyst with X-ray-stimulated Cu+active sites can accelerate Fenton-like catalysis of ·OH production by responding to endogenous H2O2for the selective killing of tumor cells rather than normal cells. In this way, the sequential combination of NIR-triggered photocatalytic O2production and X-ray-accelerated Fenton-like reaction can lead to a comprehensive radiosensitization. Overall, this synergism underscores a controllable and precise therapy modality for simultaneously unlocking the hypoxia and non-selectivity in radiotherapy. © 2022 American Chemical Society. All rights reserved. |
| 电子版国际标准刊号 | 1936086X |
| 语种 | 英语 |
| WOS记录号 | WOS:000891805600001 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/299094]  |
| 专题 | 高能物理研究所_多学科研究中心 高能物理研究所_加速器中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Wang, Dongmei,,Liao, You,,Yan, Haili,et al. In Situ Formed Z-Scheme Graphdiyne Heterojunction Realizes NIR-Photocatalytic Oxygen Evolution and Selective Radiosensitization for Hypoxic Tumors[J]. ACS Nano,2022,16(12):21186-21198. |
| APA | Wang, Dongmei,.,Liao, You,.,Yan, Haili.,Zhu, Shuang,.,Liu, Yunpeng.,...&Sun, Baoyun,.(2022).In Situ Formed Z-Scheme Graphdiyne Heterojunction Realizes NIR-Photocatalytic Oxygen Evolution and Selective Radiosensitization for Hypoxic Tumors.ACS Nano,16(12),21186-21198. |
| MLA | Wang, Dongmei,,et al."In Situ Formed Z-Scheme Graphdiyne Heterojunction Realizes NIR-Photocatalytic Oxygen Evolution and Selective Radiosensitization for Hypoxic Tumors".ACS Nano 16.12(2022):21186-21198. |
入库方式： OAI收割
来源：高能物理研究所
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