Advanced Light Source Analytical Techniques for Exploring the Biological Behavior and Fate of Nanomedicines
文献类型：期刊论文
| 作者 | Cao, MJ; Zhang, K; Zhang, SH; Wang, YL ; Chen, CY
|
| 刊名 | ACS CENTRAL SCIENCE
 |
| 出版日期 | 2022 |
| 卷号 | 8期号:8页码:1063-1080 |
| ISSN号 | 2374-7943 |
| DOI | 10.1021/acscentsci.2c006801063 |
| 文献子类 | Article |
| 英文摘要 | Exploration of the biological behavior and fate of nanoparticles, as affected by the nanomaterial-biology (nano-bio) interaction, has become progressively critical for guiding the rational design and optimization of nanomedicines to minimize adverse effects, support clinical translation, and aid in evaluation by regulatory agencies. Because of the complexity of the biological environment and the dynamic variations in the bioactivity of nanomedicines, insitu, label-free analysis of the transport and transformation of nanomedicines has remained a challenge. Recent improvements in optics, detectors, and light sources have allowed the expansion of advanced light source (ALS) analytical technologies to dig into the underexplored behavior and fate of nanomedicines in vivo. It is increasingly important to further develop ALS-based analytical technologies with higher spatial and temporal resolution, multimodal data fusion, and intelligent prediction abilities to fully unlock the potential of nanomedicines. In this Outlook, we focus on several selected ALS analytical technologies, including imaging and spectroscopy, and provide an overview of the emerging opportunities for their applications in the exploration of the biological behavior and fate of nanomedicines. We also discuss the challenges and limitations faced by current approaches and tools and the expectations for the future development of advanced light sources and technologies. Improved ALS imaging and spectroscopy techniques will accelerate a profound understanding of the biological behavior of new nanomedicines. Such advancements are expected to inspire new insights into nanomedicine research and promote the development of ALS capabilities and methods more suitable for nanomedicine evaluation with the goal of clinical translation. |
| 电子版国际标准刊号 | 2374-7951 |
| 语种 | 英语 |
| WOS记录号 | WOS:000859861600001 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/299083]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Cao, MJ,Zhang, K,Zhang, SH,et al. Advanced Light Source Analytical Techniques for Exploring the Biological Behavior and Fate of Nanomedicines[J]. ACS CENTRAL SCIENCE,2022,8(8):1063-1080. |
| APA | Cao, MJ,Zhang, K,Zhang, SH,Wang, YL,&Chen, CY.(2022).Advanced Light Source Analytical Techniques for Exploring the Biological Behavior and Fate of Nanomedicines.ACS CENTRAL SCIENCE,8(8),1063-1080. |
| MLA | Cao, MJ,et al."Advanced Light Source Analytical Techniques for Exploring the Biological Behavior and Fate of Nanomedicines".ACS CENTRAL SCIENCE 8.8(2022):1063-1080. |
入库方式： OAI收割
来源：高能物理研究所
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