Simultaneous PET/fMRI revealed increased motor area input to subthalamic nucleus in Parkinson's disease
文献类型：期刊论文
| 作者 | Zang, ZX; Song, TB; Li, JP; Nie, BB ; Mei, SS; Zhang, C; Wu, T; Zhang, YQ; Lu, J
|
| 刊名 | CEREBRAL CORTEX
 |
| 出版日期 | 2022 |
| 卷号 | 33期号:1页码:167-175 |
| ISSN号 | 1047-3211 |
| 关键词 | Parkinson's disease subthalamic nucleus causal effect |
| DOI | 10.1093/cercor/bhac059 |
| 文献子类 | Article |
| 英文摘要 | Invasive electrophysiological recordings in patients with Parkinson's disease (PD) are extremely difficult for cross-sectional comparisons with healthy controls. Noninvasive approaches for identifying information flow between the motor area and the subthalamic nucleus (STN) are critical for evaluation of treatment strategy. We aimed to investigate the direction of the cortical-STN hyperdirect pathway using simultaneous F-18-FDG-PET/functional magnetic resonance imaging (fMRI). Data were acquired during resting state on 34 PD patients and 25 controls. The ratio of standard uptake value for PET images and the STN functional connectivity (FC) maps for fMRI data were generated. The metabolic connectivity mapping (MCM) approach that combines PET and fMRI data was used to evaluate the direction of the connectivity. Results showed that PD patients exhibited both increased FDG uptake and STN-FC in the sensorimotor area (P-FDR < 0.05). MCM analysis showed higher cortical-STN MCM value in the PD group (F = 6.63, P = 0.013) in the left precentral gyrus. There was a high spatial overlap between the increased glucose metabolism and increased STN-FC in the sensorimotor area in PD. The MCM approach further revealed an exaggerated cortical input to the STN in PD, supporting the precentral gyrus as a target for treatment such as the repetitive transcranial magnetic stimulation. |
| 电子版国际标准刊号 | 1460-2199 |
| 语种 | 英语 |
| WOS记录号 | WOS:000759771700001 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/299308]  |
| 专题 | 高能物理研究所_核技术应用研究中心 高能物理研究所_管理与技术支持 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Zang, ZX,Song, TB,Li, JP,et al. Simultaneous PET/fMRI revealed increased motor area input to subthalamic nucleus in Parkinson's disease[J]. CEREBRAL CORTEX,2022,33(1):167-175. |
| APA | Zang, ZX.,Song, TB.,Li, JP.,Nie, BB.,Mei, SS.,...&Lu, J.(2022).Simultaneous PET/fMRI revealed increased motor area input to subthalamic nucleus in Parkinson's disease.CEREBRAL CORTEX,33(1),167-175. |
| MLA | Zang, ZX,et al."Simultaneous PET/fMRI revealed increased motor area input to subthalamic nucleus in Parkinson's disease".CEREBRAL CORTEX 33.1(2022):167-175. |
入库方式： OAI收割
来源：高能物理研究所
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