Altered functional connectivity and topology structures in default mode network induced by inflammatory exposure in aged rat: A resting-state functional magnetic resonance imaging study
文献类型：期刊论文
| 作者 | Liu, Y; Feng, HR; Fu, HQ; Wu, Y; Nie, BB ; Wang, TL
|
| 刊名 | FRONTIERS IN AGING NEUROSCIENCE
 |
| 出版日期 | 2022 |
| 卷号 | 14页码:1013478 |
| 关键词 | anesthesia inflammation cognitive dysfunction default mode network small worldness |
| ISSN号 | 1663-4365 |
| DOI | 10.3389/fnagi.2022.1013478 |
| 文献子类 | Article |
| 英文摘要 | Inflammatory stress in anesthesia management and surgical process has been reported to induce long-term cognitive dysfunction in vulnerable aged brain, while few studies focused on the network mechanism. The default mode network (DMN) plays a significant role in spontaneous cognitive function. Changes in topology structure and functional connectivity (FC) of DMN in vulnerable aged brain following inflammatory stress-induced long-term cognitive dysfunction are rarely studied. Eighty-eight aged male rats received intraperitoneal injection of lipopolysaccharide (LPS) as treatment or equal amount of normal saline (NS) as control. Morris Water Maze (MWM) was performed to assess short- (<7 days) and long-term (>30 days) learning and spatial working memory. Enzyme-linked immunosorbent assay (ELISA) was used to measure systemic and hippocampus inflammatory cytokines. Real-time polymerase chain reaction (RT-PCR) was used to measure the changes in gene level. Resting-state functional magnetic resonance imaging (rs-fMRI) was used to exam brain function prior to MWM on days 3, 7, and 31 after LPS exposure. Graph theory analysis was used to analyze FC and topology structures in aged rat DMN. Aged rats treated with LPS showed short- and long-term impairment in learning and spatial working memory in MWM test. Graph theory analysis showed temporary DMN intrinsic connectivity increased on day 3 followed with subsequent DMN intrinsic connectivity significantly altered on day 7 and day 31 in LPS-exposed rats as compared with controls. Short- and long-term alterations were observed in FC, while alterations in topology structures were only observed on day 3. Rats with inflammatory stress exposure may cause short- and long-term alterations in intrinsic connectivity in aged rat's DMN while the changes in topology structures only lasted for 3 days. Inflammatory stress has prolonged effects on FC, but not topology structures in venerable aged brain. |
| 语种 | 英语 |
| WOS记录号 | WOS:000892744600001 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/299480]  |
| 专题 | 高能物理研究所_核技术应用研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Liu, Y,Feng, HR,Fu, HQ,et al. Altered functional connectivity and topology structures in default mode network induced by inflammatory exposure in aged rat: A resting-state functional magnetic resonance imaging study[J]. FRONTIERS IN AGING NEUROSCIENCE,2022,14:1013478. |
| APA | Liu, Y,Feng, HR,Fu, HQ,Wu, Y,Nie, BB,&Wang, TL.(2022).Altered functional connectivity and topology structures in default mode network induced by inflammatory exposure in aged rat: A resting-state functional magnetic resonance imaging study.FRONTIERS IN AGING NEUROSCIENCE,14,1013478. |
| MLA | Liu, Y,et al."Altered functional connectivity and topology structures in default mode network induced by inflammatory exposure in aged rat: A resting-state functional magnetic resonance imaging study".FRONTIERS IN AGING NEUROSCIENCE 14(2022):1013478. |
入库方式： OAI收割
来源：高能物理研究所
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