Preparative purification of polyethylene glycol derivatives with polystyrene-divinylbenzene beads as chromatographic packing
文献类型：期刊论文
| 作者 | Yu, Pengzhan; Li, Xingqi; Li, Xiunan; Lu, Xiuling; Ma, Guanghui; Su, Zhiguo |
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2007-10-15 |
| 卷号 | 17期号:20页码:5605-5609 |
| 关键词 | polystyrene-divinyl benzene beads purification of polyethylene glycol derivatives preparative reversed-phase chromatography |
| ISSN号 | 0960-894X |
| 其他题名 | Bioorg. Med. Chem. Lett. |
| 中文摘要 | A clear and powerful chromatographic approach to purify polyethylene glycol derivatives at a preparative scale was reported, which was based on the polystyrene-divinylbenzene beads with ethanol/water as eluants. The validity of this method was verified with the reaction mixture of mPEG-Glu and mPEG propionaldehyde diethylacetal (ALD-PEG) as the model. The target products were one-step achieved with the purity of > 99% on the polymer resins column at gram scale. The method developed was free from such disadvantages as utility of toxic solvent and narrow application scope, which was combined with conventional approaches. The method developed provided an appealing and attractive alternative methods for purification of PEG derivatives at a preparative scale. (c) 2007 Elsevier Ltd. All rights reserved. |
| 英文摘要 | A clear and powerful chromatographic approach to purify polyethylene glycol derivatives at a preparative scale was reported, which was based on the polystyrene-divinylbenzene beads with ethanol/water as eluants. The validity of this method was verified with the reaction mixture of mPEG-Glu and mPEG propionaldehyde diethylacetal (ALD-PEG) as the model. The target products were one-step achieved with the purity of > 99% on the polymer resins column at gram scale. The method developed was free from such disadvantages as utility of toxic solvent and narrow application scope, which was combined with conventional approaches. The method developed provided an appealing and attractive alternative methods for purification of PEG derivatives at a preparative scale. (c) 2007 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
| 类目[WOS] | Chemistry, Medicinal ; Chemistry, Organic |
| 研究领域[WOS] | Pharmacology & Pharmacy ; Chemistry |
| 关键词[WOS] | POLY(ETHYLENE GLYCOL) ; PROTEIN MODIFICATION ; SITE ; PEGYLATION ; AGENTS ; PEGS |
| 收录类别 | SCI |
| 原文出处 | |
| 语种 | 英语 |
| WOS记录号 | WOS:000250287600023 |
| 公开日期 | 2013-10-15 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/3497]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Pengzhan,Li, Xingqi,Li, Xiunan,et al. Preparative purification of polyethylene glycol derivatives with polystyrene-divinylbenzene beads as chromatographic packing[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2007,17(20):5605-5609. |
| APA | Yu, Pengzhan,Li, Xingqi,Li, Xiunan,Lu, Xiuling,Ma, Guanghui,&Su, Zhiguo.(2007).Preparative purification of polyethylene glycol derivatives with polystyrene-divinylbenzene beads as chromatographic packing.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,17(20),5605-5609. |
| MLA | Yu, Pengzhan,et al."Preparative purification of polyethylene glycol derivatives with polystyrene-divinylbenzene beads as chromatographic packing".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 17.20(2007):5605-5609. |
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来源：过程工程研究所
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