BNCT中子源的研发现况与展望
文献类型：期刊论文
| 作者 | Fu, Shinian,,; Liang, Tianjiao,,; Chen, Hesheng,, |
| 刊名 | Kexue Tongbao/Chinese Science Bulletin
 |
| 出版日期 | 2022 |
| 卷号 | 67期号:14页码:1471-1478 |
| ISSN号 | 0023074X |
| DOI | 10.1360/TB-2021-1254 |
| 文献子类 | Article |
| 英文摘要 | Boron neutron capture therapy (BNCT) is regarded as a revolutionary means for high-accuracy cancer therapy with cell-level selectivity. It has unique therapeutic effects for some malignancies, such as glioblastoma multiforme, melanoma, recurrent head and neck malignancy. It can also be used for cancer treatment of deep organ, such as liver and lung. Even though its principle was proposed about 80 years ago, it has never been utilized in routine clinic therapy in hospital until 2020. BNCT, as a binary therapeutic method, greatly depends on both high-quality neutron beam and highly target-selective boron drug. Tumor killing in cell-level accuracy can be achieved only when the two elements work together and collaborate closely. To realize such therapeutic effect, BNCT sets high requirement on both neutron source and boron drug. The research on boron drug is related with multi-disciplines, such as chemistry, biology, medicine, radiology, pharmacy and physics. This article focuses on the neutron source for BNCT. Commonly, there are two types of BNCT neutron sources: reactor-based neutron source and accelerator-based neutron source. Up to now, almost all clinic trials of BNCT therapy were performed with the former. Due to limited resources of reactor neutron source, only less than 2000 cases BNCT treatments have been carried out in the world since BNCT method was invented. Thanks to the intense beam proton accelerator development, accelerator based neutron source can provide better beam quality, and especially important it can be installed in a hospital environment, which is essential for wide-range application of BNCT. In accelerator-based BNCT field, China has a sound base owing to more than 20 years research and development in high intensity neutron source for spallation neutron source and accelerator-driven subcritical system. It is meaningful work to transfer the related technology to accelerator-based BNCT (AB-BNCT). In this paper we will firstly introduce the demand for neutron beam specification recommended by IAEA. Then the difficulties in BNCT slow development in passing decades are reviewed. A new era of BNCT is coming and one can expect a prosperous future, owing to accelerator-based BNCT. The core technology of AB-BNCT is explored and recent research achievements on BNCT research and development in China are reported. Various types of accelerators now can be used for BNCT facility, including electro-static high voltage, cyclotron and RF linac. Their pro and con are reviewed. Majorly two kinds of neutron generation targets are utilized for BNCT, and the characteristics comparison of these two are analyzed. On the newly constructed BNCT research platform in China, new boron drug research and development work are conducted in many institutes, universities and pharmaceutical companies. And in recent, a new AB-BNCT facility is under construction for clinic trials in a hospital. So we can have an optimistic viewpoint for BNCT future in China. © 2022, Science Press. All right reserved. |
| 电子版国际标准刊号 | 20959419 |
| 语种 | 中文 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/299825]  |
| 专题 | 高能物理研究所_东莞分部 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Fu, Shinian,,,Liang, Tianjiao,,,Chen, Hesheng,,. BNCT中子源的研发现况与展望[J]. Kexue Tongbao/Chinese Science Bulletin,2022,67(14):1471-1478. |
| APA | Fu, Shinian,,,Liang, Tianjiao,,,&Chen, Hesheng,,.(2022).BNCT中子源的研发现况与展望.Kexue Tongbao/Chinese Science Bulletin,67(14),1471-1478. |
| MLA | Fu, Shinian,,,et al."BNCT中子源的研发现况与展望".Kexue Tongbao/Chinese Science Bulletin 67.14(2022):1471-1478. |
入库方式： OAI收割
来源：高能物理研究所
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