Ag-Activated Metal-Organic Framework with Peroxidase-like Activity Synergistic Ag+ Release for Safe Bacterial Eradication and Wound Healing
文献类型：期刊论文
| 作者 | Zhou, J; Chen, N; Liao, J; Tian, G; Mei, LQ; Yang, GP; Wang, Q ; Yin, WY
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| 刊名 | NANOMATERIALS
 |
| 出版日期 | 2022 |
| 卷号 | 12期号:22页码:4058 |
| 关键词 | antibacterial silver ions release nanozyme metal-organic framework wound healing |
| DOI | 10.3390/nano12224058 |
| 文献子类 | Article |
| 英文摘要 | Silver nanoparticles (Ag NPs), a commonly used antibacterial nanomaterial, exhibit broad-spectrum antibacterial activity to combat drug-resistant bacteria. However, the Ag NPs often causes a low availability and high toxicity to living bodies due to their easy aggregation and uncontrolled release of Ag+ in the bacterial microenvironment. Here, we report a porous metal-organic framework (MOF)-based Zr-2-amin-1,4-NH2-benzenedicarboxylate@Ag (denoted as UiO-66-NH2-Ag) nanocomposite using an in-situ immobilization strategy where Ag NPs were fixed on the UiO-66-NH2 for improving the dispersion and utilization of Ag NPs. As a result, the reduced use dose of Ag NPs largely improves the biosafety of the UiO-66-NH2-Ag. Meanwhile, after activation by the Ag NPs, the UiO-66-NH2-Ag can act as nanozyme with high peroxidase (POD)-like activity to efficiently catalyze the decomposition of H2O2 to extremely toxic hydroxyl radicals (center dot OH) in the bacterial microenvironment. Simultaneously, the high POD-like activity synergies with the controllable Ag+ release leads to enhanced reactive oxygen species (ROS) generation, facilitating the death of resistant bacteria. This synergistic antibacterial strategy enables the low concentration (12 mu g/mL) of UiO-66-NH2-Ag to achieve highly efficient inactivation of ampicillin-resistant Escherichia coli (Amp(r) E. coli) and endospore-forming Bacillus subtilis (B. subtilis). In vivo results illustrate that the UiO-66-NH2-Ag nanozyme has a safe and accelerated bacteria-infected wound healing. |
| 电子版国际标准刊号 | 2079-4991 |
| 语种 | 英语 |
| WOS记录号 | WOS:000887848900001 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/299935]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Zhou, J,Chen, N,Liao, J,et al. Ag-Activated Metal-Organic Framework with Peroxidase-like Activity Synergistic Ag+ Release for Safe Bacterial Eradication and Wound Healing[J]. NANOMATERIALS,2022,12(22):4058. |
| APA | Zhou, J.,Chen, N.,Liao, J.,Tian, G.,Mei, LQ.,...&Yin, WY.(2022).Ag-Activated Metal-Organic Framework with Peroxidase-like Activity Synergistic Ag+ Release for Safe Bacterial Eradication and Wound Healing.NANOMATERIALS,12(22),4058. |
| MLA | Zhou, J,et al."Ag-Activated Metal-Organic Framework with Peroxidase-like Activity Synergistic Ag+ Release for Safe Bacterial Eradication and Wound Healing".NANOMATERIALS 12.22(2022):4058. |
入库方式： OAI收割
来源：高能物理研究所
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