Synthesis of monomethoxy poly(ethylene glycol) without diol poly(ethylene glycol)
文献类型：期刊论文
| 作者 | Zhang, Jing; Zhao, Yong-Jiang; Su, Zhi-Guo; Ma, Guang-Hui |
| 刊名 | JOURNAL OF APPLIED POLYMER SCIENCE
 |
| 出版日期 | 2007-09-15 |
| 卷号 | 105期号:6页码:3782-3786 |
| 关键词 | anionic polymerization ring-opening polymerization polyethers high molecular weight high purity |
| ISSN号 | 0021-8995 |
| 其他题名 | J. Appl. Polym. Sci. |
| 中文摘要 | Since monomethoxy poly(ethylene glycol) (mPEG) inevitably contains diol PEG and is difficult to get high molecular weight through traditional synthesis at high temperature under high pressure, a novel synthetic technique via anionic solution polymerization was reported in this study. With a new initiating system, potassium naphthalene and methanol, was introduced, the polymerization proceeded at ambient temperature and side reactions were well restrained. Furthermore, a slight excess of potassium naphthalene can effectively remove the trace of water and oxygen in the reaction system. Under this condition, mPEG was nearly quantitatively obtained without containing diol PEG. Its Mn ranged from 1 to 30 kDa and the polydispersity was kept lower than 1.07. Characterization of the mPEG obtained was carried out using GPC to determine the content of diol PEG and (1)H-NMR and MALDI-ToF MS spectroscopic analysis to confirm the exact structure. (c) 2007 Wiley Periodicals, Inc. |
| 英文摘要 | Since monomethoxy poly(ethylene glycol) (mPEG) inevitably contains diol PEG and is difficult to get high molecular weight through traditional synthesis at high temperature under high pressure, a novel synthetic technique via anionic solution polymerization was reported in this study. With a new initiating system, potassium naphthalene and methanol, was introduced, the polymerization proceeded at ambient temperature and side reactions were well restrained. Furthermore, a slight excess of potassium naphthalene can effectively remove the trace of water and oxygen in the reaction system. Under this condition, mPEG was nearly quantitatively obtained without containing diol PEG. Its Mn ranged from 1 to 30 kDa and the polydispersity was kept lower than 1.07. Characterization of the mPEG obtained was carried out using GPC to determine the content of diol PEG and (1)H-NMR and MALDI-ToF MS spectroscopic analysis to confirm the exact structure. (c) 2007 Wiley Periodicals, Inc. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Polymer Science |
| 研究领域[WOS] | Polymer Science |
| 关键词[WOS] | MALDI-TOF-MS ; PROTEIN PEGYLATION ; ETHYLENE-OXIDE ; POLYMERIZATION ; DERIVATIVES ; PEPTIDE ; ETHERS ; DRUGS ; END |
| 收录类别 | SCI |
| 原文出处 | |
| 语种 | 英语 |
| WOS记录号 | WOS:000248320000078 |
| 公开日期 | 2013-10-15 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/3517]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Jing,Zhao, Yong-Jiang,Su, Zhi-Guo,et al. Synthesis of monomethoxy poly(ethylene glycol) without diol poly(ethylene glycol)[J]. JOURNAL OF APPLIED POLYMER SCIENCE,2007,105(6):3782-3786. |
| APA | Zhang, Jing,Zhao, Yong-Jiang,Su, Zhi-Guo,&Ma, Guang-Hui.(2007).Synthesis of monomethoxy poly(ethylene glycol) without diol poly(ethylene glycol).JOURNAL OF APPLIED POLYMER SCIENCE,105(6),3782-3786. |
| MLA | Zhang, Jing,et al."Synthesis of monomethoxy poly(ethylene glycol) without diol poly(ethylene glycol)".JOURNAL OF APPLIED POLYMER SCIENCE 105.6(2007):3782-3786. |
入库方式： OAI收割
来源：过程工程研究所
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