Polarized Autologous Macrophages (PAM) Can Be a Tumor Vaccine
文献类型：期刊论文
| 作者 | Wang, DQ ; Chen, HY; Hu, Y
|
| 刊名 | ONCOLOGIE
 |
| 出版日期 | 2022 |
| 卷号 | 24期号:3页码:441-449 |
| ISSN号 | 1292-3818 |
| 关键词 | Polarized autologous macrophages immunotherapy solid tumors vaccine hydrogel |
| DOI | 10.32604/oncologie.2022.024898 |
| 文献子类 | Article |
| 英文摘要 | Immunotherapy is currently recognized as one of the most promising anticancer strategies. In the tumor micro -environment, tumor-associated macrophages are mainly M2-type macrophages with tumor-promoting effects. Therefore, the reprogramming of tumor-associated macrophages from M2 to M1 type is a potential strategy for cancer therapy. We have previously shown the anticancer effects of implantable allogeneic M1 macrophages in mice. Here, we further engineered autologous mouse bone marrow cells into M1 macrophages and then embedded them into a sodium alginate gel to prepare an implantable immunotherapeutic agent (M1@Gel). We demonstrate that M1@Gel repolarizes M2 macrophages to M1 type and activates the immune responses in mice. As a result, M1@Gel can potently inhibit the tumor recurrence in mice after the surgical tumor removal. These results suggest that the implantation of autologous M1 macrophages might be a promising strategy for pre-venting postoperative tumor recurrence. We envisage that the employment of polarized autologous macrophages as a tumor vaccine might be translated into clinic. |
| 电子版国际标准刊号 | 1765-2839 |
| 语种 | 英语 |
| WOS记录号 | WOS:000863681900005 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/300061]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Wang, DQ,Chen, HY,Hu, Y. Polarized Autologous Macrophages (PAM) Can Be a Tumor Vaccine[J]. ONCOLOGIE,2022,24(3):441-449. |
| APA | Wang, DQ,Chen, HY,&Hu, Y.(2022).Polarized Autologous Macrophages (PAM) Can Be a Tumor Vaccine.ONCOLOGIE,24(3),441-449. |
| MLA | Wang, DQ,et al."Polarized Autologous Macrophages (PAM) Can Be a Tumor Vaccine".ONCOLOGIE 24.3(2022):441-449. |
入库方式： OAI收割
来源：高能物理研究所
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