Chemical transformation and cytotoxicity of iron oxide nanoparticles (IONPs) accumulated in mitochondria
文献类型：期刊论文
| 作者 | Ruan, Lifo; Li, Haijing; Zhang, Jiayu; Zhou, Mengxue; Huang, Hui; Dong, Juncai ; Li, Jinxia; Zhao, Feng; Wu, Zhonghua; Chen, Jun
|
| 刊名 | Talanta
 |
| 出版日期 | 2022 |
| 卷号 | 251页码:123770 |
| ISSN号 | 00399140 |
| DOI | 10.1016/j.talanta.2022.123770 |
| 文献子类 | Article |
| 英文摘要 | Iron oxide nanoparticles (IONPs) have been widely used as a nanoscale tool in biomedical research. However, it remains largely unknown how IONPs are transformed at a subcellular level to elicit distinct biological effects. In the present study, we prepared three different IONPs, including two IONPs targeting mitochondria (IONP-TPP) and lysosomes (IONP-APM), respectively, and a control with no specified target (IONP). By MTT assay and JC-1 staining, mitochondria-targeted IONP-TPP was found to produce significant cytotoxicity and severe mitochondrial membrane depolarization in MCF-7 cells. Furthermore, X-ray absorption spectroscopy (XAS) analysis revealed that IONP-TPP underwent remarkable edge defects and oxidation inside the cell. These findings suggest that IONPs are prone to the chemical transformation at mitochondria, and mitochondria are vulnerable to IONPs accumulation in the cell. © 2022 Elsevier B.V. |
| 语种 | 英语 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/300397]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Ruan, Lifo,Li, Haijing,Zhang, Jiayu,et al. Chemical transformation and cytotoxicity of iron oxide nanoparticles (IONPs) accumulated in mitochondria[J]. Talanta,2022,251:123770. |
| APA | Ruan, Lifo.,Li, Haijing.,Zhang, Jiayu.,Zhou, Mengxue.,Huang, Hui.,...&Hu, Yi.(2022).Chemical transformation and cytotoxicity of iron oxide nanoparticles (IONPs) accumulated in mitochondria.Talanta,251,123770. |
| MLA | Ruan, Lifo,et al."Chemical transformation and cytotoxicity of iron oxide nanoparticles (IONPs) accumulated in mitochondria".Talanta 251(2022):123770. |
入库方式： OAI收割
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。